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Biological active bone tissue inducing regeneration film and preparation method

A technology of biological activity and biological active factors, applied in the field of medical materials and their preparation, can solve the problems of non-tissue induction, achieve huge social and economic benefits, mature technology and easy control.

Inactive Publication Date: 2005-07-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two types of membranes, like foreign products, only have the basic properties of medical membranes, and also do not have tissue induction.

Method used

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  • Biological active bone tissue inducing regeneration film and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 2 grams of polylactic acid with a viscosity of 3.51 with a balance, add it to 40ml of ethyl acetate, and swell at room temperature for 12 hours, stir and dissolve for 1 hour, and after defoaming for 1 hour, pour it into a 10×10cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put it into a semi-closed container to slowly volatilize ethyl acetate for 1 day, then open and volatilize for 2 days, then vacuum dry at 70°C for 8 hours to remove residual of ethyl acetate.

[0025] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demolding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the cow 0.5 g of collagen was dissolved in 0.01M acetic acid and made into a 3% collagen solution, which was evenly spread on the scratched membrane surface, and then evaporated and dried naturally at room te...

Embodiment 2

[0029] Use a balance to weigh 3 grams of polylactic acid with a viscosity of 3.32, add it to 50ml of ethyl acetate, and swell at room temperature for 15 hours, stir and dissolve for 2 hours, and after defoaming for 1 hour, pour it into a 14×14cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put it into a semi-closed container to slowly volatilize ethyl acetate for 2 days, then open it for 1 day and then vacuum dry it at 60°C for 6 hours to remove residual of ethyl acetate.

[0030] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demolding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the pig 1.0 g of collagen was dissolved in 0.01M acetic acid and made into a 1% collagen solution, which was evenly spread on the scratched membrane surface, and then evaporated and dried naturally at room tempe...

Embodiment 3

[0034] Use a balance to weigh 3 grams of polylactic acid with a viscosity of 3.78, add it to 100ml of ethyl acetate, and swell at room temperature for 18 hours, stir and dissolve for 2 hours, and after defoaming for 2 hours, pour it into a 14×14cm flat mold. What this embodiment chooses is flat flow casting film on flat glass mold, then put into semi-closed container and volatilize ethyl acetate slowly for 2 days, then open and volatilize for 2 days, then vacuum dry at 80°C for 10 hours to remove residual of ethyl acetate.

[0035] Under the condition that the prepared polylactic acid membrane is separated from the surrounding membrane without demolding, use a probe to scratch and roughen the surface to form staggered scratches with a depth of 1 to 10 microns, and then place the cow 1.0 g of collagen was dissolved in 0.01M acetic acid and made into a 2% collagen solution, evenly spread on the scratched membrane surface, and allowed to evaporate and dry naturally at room temper...

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Abstract

The bioactive bone tissue induction regeneration membrane disclosed by the invention has a two-layer composite structure, one layer is polylactic acid, and the other layer is a mixture of collagen fibers and bioactive factor recombinant human gene bone morphogenic protein. The film is made on the polylactic acid base film made by swelling→stirring and dissolving→degassing→film making process, roughened by scratches, coated with collagen fiber solution, and then coated with collagen fibers and recombinant human bioactive factors. Genetic bone morphogenic protein mixture, obtained by freezing and vacuum drying. In addition to a series of basic properties expected in clinical practice, the obtained diaphragm also has osteoinductive activity, which can regenerate new bone at the damaged bone site, so it can be widely used in orthopedics, craniofacial surgery, maxillofacial surgery, dental implantology, Multiple clinical disciplines such as periodontal surgery and restorative and reconstructive surgery have huge social and economic benefits.

Description

1. Technical field [0001] The invention belongs to the technical field of medical materials and preparation methods thereof, and in particular relates to a medical biofilm material capable of inducing bone tissue regeneration and a preparation method thereof. 2. Background technology [0002] Clinically, tissue defects caused by various reasons are very common. In order to provide regeneration space for the self-repair of the defective tissue and achieve the purpose of morphological and functional reconstruction, a bio-diaphragm is usually installed between the defective tissue site and other tissues in clinical practice. Generally speaking, in addition to functioning as a barrier between different tissues, the biomembrane used in the body also requires good compatibility and the ability to degrade in vivo. However, with the continuous development of medical material technology and the improvement of clinical use requirements, people also hope to obtain a diaphragm with tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/16
Inventor 田卫东包崇云李声伟刘磊
Owner SICHUAN UNIV