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Multi-element biological medical composite material containing apatite and its preparation method

A composite material and biomedical technology, applied in the field of multi-component biomedical composite materials and their preparation

Inactive Publication Date: 2006-01-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] By blending nano-apatite crystals and two or more polymer components in a multi-form bioactive composite material, the biological activity of the composite material can be improved, and the heat resistance and stability of the composite material can be improved. performance and processing performance, comprehensively utilize the respective advantages of different materials, complement each other, and develop high-performance clinical medical materials that meet the needs of the market, which is the frontier and key direction of international biomedical material research. see reports

Method used

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  • Multi-element biological medical composite material containing apatite and its preparation method
  • Multi-element biological medical composite material containing apatite and its preparation method
  • Multi-element biological medical composite material containing apatite and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Nanoapatite slurry adopts literature Li Yubao, J.de Wijn, C.PA.T.Klein, S.v.d.Meer and K.de Groot, Preparation and Characterization of Nanograde Osteoapatite-like RodCrystals, J. Mater. Sci.: Mater. in Med., 5(1994): 252-255 was prepared by wet synthesis and hydrothermal treatment (water content 66%). The nano-apatite (n-AP) slurry was dried at 100°C, ground, and passed through a 200-mesh sieve. Polyamide 66 (PA66), high density polyethylene (HDPE) was vacuum dried at 90°C. The weight ratio is n-AP / PA66 / HDPE=40 / 30 / 30. The three materials are put into a mixer and mixed evenly, and then added into a TSE-30A twin-screw mixing extruder for melt blending and extrusion. The set melting temperature zones are: 180°C, 225°C, 250°C, 255°C, 255°C and 250°C in sequence; the speed of the main screw is 140 rpm, and the speed of the feeding screw is 14 rpm. After the extruded product was cooled in a water tank, it was granulated by a pelletizer with a rotating speed of 12 rpm to ob...

Embodiment 2

[0044] The nano-apatite slurry and other operating methods and conditions are the same as in Example 1, and the three materials are added to the mixer for mixing according to the weight ratio of n-AP / PA66 / HDPE=40 / 36 / 24, and then TSE- 30A type twin-screw mixing extruder for melt extrusion. Set the melting temperature zone as follows: 190°C, 230°C, 255°C, 260°C, 260°C and 255°C; main screw speed: 140 rpm, feeding screw speed: 14 rpm; granulator speed: 11 revs / min, granulate, make n-AP / PA66 / HDPE (40 / 36 / 24) composite material pellet.

Embodiment 3

[0046] The nano-apatite slurry and other operating methods and conditions are the same as in Example 1, and the weight ratio is n-AP / PA66 / HDPE=40 / 42 / 18. Put the three materials into the mixer and mix them evenly, and then add TSE -30A type twin-screw mixing extruder for melt extrusion. The set melting temperature zones are: 210°C, 235°C, 260°C, 265°C, 265°C and 260°C; the speed of the main screw is 140 rpm, the speed of the feeding screw is 14 rpm; the speed of the pelletizer 10 revs / min, granulation to prepare n-AP / PA66 / HDPE (40 / 42 / 18) composite pellets.

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Abstract

A medical multi-element biological composition containing apatite is prepared from apatite nanoparticles, medical polyamide or the biodegradable polymer of polyamide, and at least one medical high-molecular material through proportional mixing and dual-screen pugging. Its advantages are high toughness, elastic modulus and strength of break.

Description

technical field [0001] The invention relates to a multi-component biomedical composite material containing apatite which can be used for replacing and repairing hard tissue defects in medical surgery and a preparation method thereof. Background technique [0002] Due to the nano-apatite's own structure and unique biological activity, people have obtained various forms of biomedical composite materials by combining nano-apatite with other materials. At present, the research on these aspects mainly focuses on the following aspects: the compounding of nano-apatite and natural polymer; the compounding of nano-apatite and synthetic polymer; the compounding of nano-apatite and metal alloy; Compounding of nano-apatite and inorganic substances; compounding of nano-apatite and drugs. [0003] The research on multi-component composite materials containing three or more components of nano-apatite has just started, and the main ones that have been reported so far are: apatite / polymer m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/48A61L27/42
Inventor 李玉宝左奕
Owner SICHUAN UNIV