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Method for preparing Gadol pharmaceutical preparation

A pharmaceutical preparation, Rhodiola rosea technology, applied in the direction of medical formula, drug combination, plant raw materials, etc., can solve the problems of discomfort in the treatment of cardiovascular and other acute diseases, long heating time, large loss of active ingredients, etc., to achieve increased uniformity and Stability, improved safety, and short heating time

Inactive Publication Date: 2006-05-10
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, rhodiola preparations are mainly oral preparations. When extracting Jingtian extract, water extraction technology is often used, without removing too many ineffective ingredients, the content of active ingredients is low, and the preparation process and preparation are backward; Oral administration of solid preparations takes effect slowly, and is not suitable for the treatment of acute diseases such as cardiovascular diseases, and the solid preparations are heated for a long time during the preparation process, the loss of active ingredients is large, and the quality of the preparations varies greatly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1. Preparation of Rhodiola rosea freeze-dried powder injection.

[0011] Take 60 grams of rhodiola rosea, add 50% ethanol to extract by warm soaking at 70°C, recover ethanol under reduced pressure, concentrate, dilute with water, let stand, filter, the filtrate is adsorbed by macroporous adsorption resin, rinse with distilled water until the effluent is colorless , eluted with dilute ethanol, collected the eluate, recovered the ethanol under reduced pressure at 75°C and -0.5MPa until there was no alcohol smell, and obtained the Rhodiola rosea extract; take the Rhodiola rosea extract, dissolve it in water for injection, add 0.5% mannitol, stand still, filter, the filtrate is ultrafiltered with a 10000 Dalton filter membrane, supplemented with water for injection to the ultrafiltrate, the ultrafiltrate is aseptically divided into sterilized vials, freeze-dried, and stoppered, Press the cap to obtain the Rhodiola rosea freeze-dried powder injection, and the conten...

Embodiment 2

[0012] Example 2. Preparation of Rhodiola rosea freeze-dried powder injection.

[0013] Take 600 grams of Rhodiola rosea, add 80% ethanol to extract by warm soaking at 80°C, recover ethanol under reduced pressure, concentrate, dilute with water, let stand, filter, the filtrate is adsorbed by macroporous adsorption resin, rinse with distilled water until the effluent is colorless , eluted with dilute ethanol, collected the eluate, recovered the ethanol under reduced pressure at 70°C and -1.0MPa until there was no alcohol smell, and obtained the Rhodiola rosea extract; take the Rhodiola rosea extract, dissolve it in water for injection, add 1.0% mannitol, stand still, filter, the filtrate is ultrafiltered with a 30000 Dalton filter membrane, add water for injection to the ultrafiltrate, the ultrafiltrate is aseptically packed in sterilized vials, freeze-dried, and stoppered, Press the cap to obtain the Rhodiola rosea freeze-dried powder injection, and the content of salidroside...

Embodiment 3

[0014] Example 3. Preparation of Rhodiola rosea freeze-dried powder injection.

[0015] Take 6000 grams of Rhodiola rosea, add 70% ethanol to warm soak at 75°C, recover ethanol under reduced pressure, concentrate, add water to dilute, let stand, filter, the filtrate is adsorbed by macroporous adsorption resin, rinse with distilled water until the effluent is colorless , eluted with dilute ethanol, collected the eluate, recovered the ethanol under reduced pressure at 80°C and -0.8MPa until there was no alcohol smell, and obtained the Rhodiola rosea extract; take the Rhodiola rosea extract, add water for injection to dissolve, add 2.0% mannitol, stand still, filter, the filtrate is ultrafiltered with a 20000 Dalton filter membrane, add water for injection to the ultrafiltrate, the ultrafiltrate is aseptically packed in sterilized vials, freeze-dried, and stoppered. Press the cap to get the Rhodiola rosea freeze-dried powder injection.

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PUM

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Abstract

The invention discloses a method for preparing a Rhodiola rosea pharmaceutical preparation. The dosage form of the preparation is a powder injection, which is a composition made of Rhodiola rosea extract and freeze-dried powder injection proppant. The active ingredient in the composition is The content of salidroside is not less than 25%; the present invention effectively removes macromolecular substances, pigments, resins, tannins and other harmful components through the secondary alcohol precipitation process or macroporous resin adsorption process, and the active components are completely retained, making the preparation safe and stable , high curative effect, quick effect, can be used for the treatment of cardiovascular disease.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation using Chinese herbal medicine as a raw material, in particular to a preparation method of a rhodiola rosea pharmaceutical preparation. Background technique [0002] Rhodiola is a plant of the Sedum family Rhodiola (Rhodiola L.), which is a perennial herb or subshrub. There are 73 species in my country, which are distributed in the northeast, north, northwest and southwest regions. Rhodiola rosea is mainly distributed in North my country in China, Rhodiola alpine and Rhodiola Changbai are mainly distributed in Changbai Mountains, and Rhodiola small clusters are distributed in North China and northeast China. Distributed across regions. After 20 to 30 years of research by many scientists in the Soviet Union, Rhodiola was found to be more effective than ginseng and Acanthopanax. Ginseng has a strong excitatory effect, Acanthopanax can cause constipation,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/41A61K31/7028A61K9/19A61P9/10
Inventor 肖伟戴翔翎凌娅王振中尚强
Owner JIANGSU KANION PHARMA CO LTD