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Radix bupleuri soft capsule pharmaceutics and preparation process thereof

A technology of soft capsule and Bupleurum, applied in the field of medicine, can solve the problems of inconvenient medication, unstable quality, inconvenient carrying and transportation, etc.

Inactive Publication Date: 2006-06-14
山东希尔康泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of the injection is certain, but there is the disadvantage of inconvenient administration; although the process of the oral solution is simple and the cost is low, the quality is not stable, precipitation is easy to occur, and it is inconvenient to carry and transport

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Component Quantity (g / granule)

[0024] Bupleurum extract equivalent to crude drug 10g

[0025] Corresponding amount of bupleurum volatile oil

[0026] Macrogol 400 0.40g

[0027] Beeswax 0.02

[0028] Glycerin 0.01

[0029] Appropriate amount of water

[0030] Capsule shell 0.22

Embodiment 2

[0032] Component Quantity (g / granule)

[0033] Bupleurum extract equivalent to crude drug 5g

[0034] Corresponding amount of bupleurum volatile oil

[0035] Peanut oil 0.26

[0036] Tween-80 0.01

[0037] Ethyl cellulose 0.02

[0038] Appropriate amount of water

[0039] Capsule shell 0.19

Embodiment 3

[0041] Component Quantity (g / granule)

[0042] Bupleurum extract equivalent to crude drug 15g

[0043] Corresponding amount of bupleurum volatile oil

[0044] Isopropanol 0.40

[0045] Propylene glycol 0.10

[0046] Soy lecithin 0.05

[0047] Capsule shell 0.25

[0048] The preparation process of embodiment is as follows:

[0049] Weigh the Bupleurum bupleuri in the prescribed amount, and extract the volatile oil therein, by steam distillation or carbon dioxide supercritical extraction, and the method is preferably supercritical extraction. Collect the obtained volatile oil and dregs. The medicinal dregs are processed as follows to obtain the Bupleurum extract: the medicinal dregs are decocted twice with 95% ethanol, the first time is 2 hours, the second time is 1 hour, the filtrate is filtered in stages, the filtrates are combined and concentrated under reduced pressure to a thick paste, and dried , you can get Bupleurum extract.

[0050] After the Bupleurum extract i...

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PUM

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Abstract

The invention relates to an oral pharmaceutical preparation of Bupleurum soft capsule and a preparation process thereof. The medicinal solution contains Bupleurum extract, Bupleurum volatile oil, solvent and stabilizer. The ratio of gelatin and glycerin in the capsule shell is 10:3.15-3.35 (weight ratio), and also contains preservatives. During preparation, the volatile oil of Bupleurum bupleuri is firstly extracted, and then pressed into soft capsules. Compared with the existing dosage form of Bupleurum bupleuri, the invention has the advantages of stable quality, convenient carrying and administration, and quick dissolution of active ingredients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Bupleurum bupleuri medicinal preparation, more specifically to a Bupleurum bupleuri soft capsule, and simultaneously the invention also relates to a preparation method of the preparation. Background technique [0002] Bupleurum bupleurum is the dried root of Bupleurum bupleuriaceae. In Chinese medicine, bupleurum bupleurum has the effect of "reconciling the exterior and interior, soothing the liver, and raising the yang". embolism. Clinical preparations of Bupleurum mainly include injections and oral solutions. The curative effect of the injection is certain, but there is the disadvantage of inconvenient administration; although the process of the oral solution is simple and the cost is low, the quality is not stable, precipitation is easy to occur, and it is inconvenient to carry and transport. Both saikosaponin and bupleurum volatile oil in Bupleurum bupleuri e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/233A61K125/00A61P31/00A61P29/00
Inventor 张卫东苏娟周耘杨杰张川
Owner 山东希尔康泰药业有限公司