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Colouring pigment of eye lense and stained eye lense therewith

A technology for ophthalmic lenses and colorants, applied in glasses/goggles, optics, instruments, etc., can solve problems such as roughness, and achieve the effect of enhanced light resistance

Inactive Publication Date: 2006-08-30
NIDEK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with respect to adding a colorant to a soft intraocular lens material for making a flexible intraocular lens, there arises a problem that the colorant will be removed from the soft intraocular lens material due to its rough molecular structure. eluted from

Method used

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  • Colouring pigment of eye lense and stained eye lense therewith
  • Colouring pigment of eye lense and stained eye lense therewith
  • Colouring pigment of eye lense and stained eye lense therewith

Examples

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preparation example Construction

[0013] Preparation of ophthalmic lens colorants

[0014] First, the method for synthesizing the compound of the coloring agent for ophthalmic lenses represented by the structural formula (1) according to the present invention will be specifically explained.

[0015] First, a compound (carbazole) represented by the following formula (2):

[0016]

[0017] It is mixed with an organic solvent such as methyl ethyl ketone or dioxane, and the mixture is stirred and refluxed at a predetermined temperature in the coexistence of a base.

[0018] When the above mixture is refluxed, the compound represented by the chemical formula (3) is added dropwise to the above mixture, and the reaction is carried out:

[0019] Cl-ROH

[0020] (3)

[0021] Wherein R represents a linear or branched alkylene group having 1 to 5 carbon atoms which may be substituted by Cl or Br. Thus, the compound represented by the following formula (4...

Embodiment 1

[0047] 16 g of carbazole, 14 g of sodium hydroxide and 7 ml of pure water were mixed with 80 ml of methyl ethyl ketone, and the resulting mixture was heated and refluxed for 30 minutes under stirring. While refluxing the resulting mixture, 13 ml of 2-chloroethanol was dropped into it within 1 hour. After the resulting mixture was refluxed for another 3 hours, 8 g of sodium hydroxide was added thereto. While refluxing the mixture, 13 ml of 2-chloroethanol was dropped into it within 1 hour. Then, the resulting mixture was refluxed for 24 hours. The reaction mixture was then left to cool to room temperature, poured into 3 liters of pure water, and extracted with ether. The ether was removed with an evaporator, and the unreacted carbazole was filtered out. From the viscous reaction mixture obtained above, N-(2-hydroxyethyl)carbazole was separated by column chromatography (silica gel / benzene). The yield was 20%.

[0048] Subsequently, 4.5 g of concentrated sulfuric acid was slowly adde...

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Abstract

A colorant for ocular lenses represented by the following formula (1): wherein A and B are each selected from the group consisting of halogens, a cyano group, a nitro group, alkyl groups, alkylsulfonyl groups and alkoxy groups; R represents a linear or branched alkylene having 1 to 5 carbon atoms; and Z is selected from the group consisting of a (meth)acryl group, a vinyl group, an allyl group and a chemical structure having such a polymerizable group.

Description

Technical field [0001] The present invention relates to a colorant for ophthalmic lenses, such as contact lenses and intraocular lenses, and a colored ophthalmic lens using the colorant. Background technique [0002] In the now-known colored intraocular lens, the transmission of light in the blue region of about 400nm to 500nm can be adjusted, which can reduce the light damage of the retina, or as a measure to solve blue vision after the intraocular lens is built in. In these colored intraocular lenses, by kneading a yellow colorant, an orange colorant, etc. into a hard intraocular lens material such as PMMA, the material of the intraocular lens is dyed yellow, orange, etc. One invention provides a soft intraocular lens for treating blue vision. A colored soft intraocular lens is obtained by adding a small amount of colorant to a flexible soft intraocular lens material. (See, JP-A-7-24052). [0003] Due to its compact molecular structure, colorants that have been kneaded in rigid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/82G02C7/04G02B1/00G02C7/00C09B69/10G02C7/02
CPCC09B69/106
Inventor 中畑义弘西村茂砂田力三木定雄桑原正树
Owner NIDEK CO LTD