Medicine composition for treating cardiovascular and cerebrovascular disease and its prepararing method

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions for the treatment of cardiovascular and cerebrovascular diseases and its preparation, to achieve the effects of easy control of product quality, avoiding unfavorable factors, and definite curative effect

Inactive Publication Date: 2006-10-04
成都厚发科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, although Astragalus Injection and Ligustrazine Injection can be used in combination in clinical practice according to needs, clinical practice shows that the combined use of different injections is often prone to compatibility reactions, and the Astragalus Injection currently used The effective medicinal ingredients of the product are obtained by the traditional boiling alcohol precipitation method. In addition to containing astragaloside, it also contains more complex components such as monosaccharides, some polysaccharides, and flavonoids.

Method used

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  • Medicine composition for treating cardiovascular and cerebrovascular disease and its prepararing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]50kg of traditional Chinese medicine Astragalus, sliced, decocted 3 times with 10 times of water for 1 hour each time, filtered, combined with water decoction, passed through a D201 macroporous resin column, washed with 200 liters of water and 100 liters of 30% ethanol in turn to remove impurities, and then used 200 liters of ethanol with a volume content of 70% were eluted, and the ethanol eluate was collected, and the ethanol was recovered under reduced pressure. The residue was dissolved in water, the aqueous solution was extracted with 20 liters of n-butanol in portions, the n-butanol extracts were combined, washed twice with 10 liters of 2% aqueous sodium hydroxide solution, and then washed with 5 liters of water for 2 times. After recovering the n-butanol Dry, pulverize, degrease with 500 ml of acetone in a Soxhlet extractor, and dry to obtain astragalus saponins. Detected by the above method, the content of astragaloside IV is greater than or equal to 20%.

[002...

Embodiment 2

[0025] 100kg of traditional Chinese medicine Astragalus, sliced, add water 15 times to decoct twice, 1.5 hours each time, filter, combine the decoction, pass through AB-8 macroporous resin column, wash with 400 liters of water and 200 liters of 40% ethanol in turn to remove impurities , and then eluted with 400 liters of 80% ethanol and collected the ethanol eluate. The eluate was recovered under reduced pressure with ethanol, dissolved in water, and its aqueous solution was extracted with 40 liters of n-butanol in fractions, and the n-butanol extracts were combined and washed with 30 liters of ammonia test solution (40 ml of concentrated ammonia water and water to make 100 ml) in fractions. After recovering n-butanol, it is dried, pulverized, and then degreased with 2000 ml of acetone under stirring and refluxing. After cooling, filter, wash with appropriate amount of acetone, and dry to obtain astragalus saponins. The content of astragaloside IV was detected to meet the req...

Embodiment 3

[0028] 100kg of traditional Chinese medicine Astragalus, sliced, decocted 3 times with 10 times of water, 1 hour each time, filtered, combined with the decoction, passed through a DM-301 macroporous resin column, washed with 400 liters of water and 200 liters of 30% ethanol in turn to remove impurities Afterwards, eluate with 400 liters of 75% ethanol and collect the ethanol eluate. After the ethanol was recovered under reduced pressure, water was added to dissolve, and the aqueous solution was extracted with 40 liters of n-butanol in fractions. After combining the n-butanol extracts, wash with 20 liters of a 5% aqueous sodium carbonate solution, and then wash with 20 liters of water. After recovering n-butanol from the extract, it is dried, and then 1000 ml of acetone is used in a Soxhlet extractor to reflux and degrease, and then dried to obtain astragaloside. The content of astragaloside IV was detected to meet the requirements.

[0029] Take 50 g of ligustrazine phosphat...

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Abstract

The medicine preparation consists of chuanxiongzine or its physiologically acceptable salt and engelitin with astragalin A content not less than 20 wt% in the weight ratio of 0.2-5 as effective medicinal components and pharmacologically acceptable supplementary material. During the preparation process, astragalus root material is processed through water decoction to obtain astragalus root extractive liquid, filtering, adsorption in macroporous resin, washing with water and ethanol solution successively, collecting the ethanol eluted liquid, eliminating ethanol, extraction with n-butanol, alkali solution washing , eliminating n-butanol, and reflux with acetone to defat to obtain engelitin. Engelitin is then mixing with chuanxiongzine compound and corresponding supplementary material to prepare the medicine preparation. Test shows that the medicine preparation has obvious synergistic effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition which is particularly suitable for treating cerebral ischemic diseases, but can also be used for treating other cardiovascular and cerebrovascular diseases and a preparation method thereof. Specifically, the invention relates to a pharmaceutical composition composed of chemical medicines and natural medicine extraction components and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a common and multiple disease, especially in the middle-aged and elderly population. According to the theory of traditional Chinese medicine, qi deficiency and blood stasis are usually one of the main causes of cardiovascular and cerebrovascular diseases, which is a syndrome of deficiency and excess, and its treatment should be to nourish qi and activate blood. Therefore, in the treatment of drugs, the Qi-boosting medicine Astragalus and the blood-activating medici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/4965A61P9/10
Inventor 陈刚周家明杨秀清
Owner 成都厚发科技开发有限公司
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