Crystalline teriparatide

A crystallization and cube technology, applied in the field of teriparatide, can solve problems such as instability
CN1281467AInactive Publication Date: 2001-01-24ELI LILLY & CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ELI LILLY & CO
Publication Date
2001-01-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

Pure, stable crystalline forms of parathyroid hormone, particularly teriparatide, are described as well as methods of preparation and purification.
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Description

technical field

[0001] The present invention relates to pure crystalline forms of parathyroid hormone. More specifically, the present invention relates to teriparatide, a crystalline form of PTH(1-34), and methods for the preparation and purification of fragments of this hormone. Background of the invention

[0002] Parathyroid hormone (PTH) is an 84 amino acid product secreted by the mammalian parathyroid gland that controls serum calcium levels through actions on various tissues including bone. Studies in humans of certain forms of PTH have demonstrated anabolic effects on bone, raising considerable concerns about their use in the treatment of osteoporosis and related bone diseases.

[0003] Using the N-terminal 34 amino acids of the bovine and human hormones, which all published reports consider biologically equivalent to the full-length hormone, it has been demonstrated that when parathyroid hormone is administered subcutaneously in a pulsatile manner , parathyroid hor...

Claims

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