Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine

Abstract

A pharmaceutical composition useful in the treatment of sneezing, itching runny nose, nasal congestion, redness of the eye, tearing, itching of the ears or palate, shortness of breath, inflammation of the bronchial mucosa, reduced Forced Expiratory Volume In One Second (FEV1), coughs, rash, itchy skin, headaches, and aches and pains associated with seasonal allergic rhinitis, perennial allergic rhinitis, common colds, otitis, sinusitus, allergy, asthma, allergic asthma and / or inflammation, in a mammalian organism in need of such treatment. The composition comprises: i) an effective amount of at least one leukotriene antagonist selected from a) montelukast, b) 1-(((R)- (3-(2-(6,7- difluoro-2- quinolinyl)ethenyl) phenyl)-3-(2- (2-hydroxy-2- propyl)phenyl) thio)methylcyclopropaneacetic acid; c) 1-(((1(R)-3 (3-(2-(2,3- dichlorothieno[3, 2-b]pyridin-5-yl) -(E)-ethenyl)phenyl) -3-(2-(1-hydroxy-1- methylethyl) phenyl)propyl) thio)methyl) cyclopropaneacetic acid; d) pranlukast; or f) [2-[[2-(4-tert -butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl]phenyl] acetic acid; or a pharmaceutically acceptable salt thereof; in admixture with ii) an effective amount of at least one antihistamine which is descarboethoxyloratidine, cetirizine, fexofenadine, ebastine, astemizole, norastemizole, epinastine, efletirizine or a pharmaceutically acceptable salt thereof.

Description

Background of the invention [0001] The present invention relates to compositions for treating allergic rhinitis and other allergic diseases. Products of the 5-lipoxygenase pathway of eicosatetraenoic acid metabolism, particularly leukotrienes, can lead to bronchoconstriction, mucus secretion, edema of the tracheal mucosa, chemotaxis and migration of cells into the inflamed trachea that occurs in asthma. Although leukotriene antagonists are effective in themselves, they are not very effective in the treatment of a variety of symptoms associated with respiratory diseases, such as seasonal allergic rhinitis, non-seasonal allergic rhinitis, common cold, sinusitis, and allergic asthma. complication. Symptoms of these disorders include sneezing, itching, runny nose, nasal congestion, bloodshot eyes, watery eyes, itchy ears or palate, and cough associated with postnasal drip. It is ideal for enhancing the effects of leukotriene antagonists, increasing their overall effectiveness. ...

AI Technical Summary

Problems solved by technology

Although leukotriene antagonists are effective in themselves, they are not very effective in the treatment of a variety of symptoms associated with respiratory diseases, such as seasonal allergic rhinitis, non-seasonal allergic rhinitis, common cold, sinusitis, and allergic asthma. complication