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Quality detection method for oral liquid for curing infantile cough due to lung-heat

A technology of oral liquid and determination method, which can be used in measuring devices, instruments, scientific instruments, etc., and can solve problems such as poor absorption, unacceptable to children, and inability to rapidly exert curative effects.

Active Publication Date: 2007-04-04
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lingyang Qingfei Powder is a powder. As a medicine for children, it is inconvenient to administer, and the taste of the medicine is bitter, which is not easy for children to accept. The powder is in the form of a solid dosage form, which is poorly absorbed and cannot quickly exert its curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental Example 1: Selection of Extraction Conditions in Content Determination

[0023] According to the fact that the hydroxyanthraquinone derivatives in rhubarb mainly exist in a bound state, it is necessary to add acid to free the hydroxyanthraquinone derivatives, and the free hydroxyanthraquinone derivatives are usually soluble in benzene, ether, chloroform, etc. In the original standard, chloroform was used to reflux for 4 hours and 3 hours. Considering the toxicity of chloroform, we made some explorations on the selection of reagents and extraction methods, and designed the following five extraction schemes: (1) After adding acid to the sample, directly add ether for extraction. Extraction; (2) adding acid to the sample and then adding dichloromethane to reflux for 2 hours; (3) adding acid to the sample and then adding dichloromethane to reflux to extract for 4 hours and 3 hours respectively; (4) adding acid to the sample and then adding dichloromethane to ref...

experiment example 2

[0026] Experimental example 2: Selection of mobile phase in content determination

[0027] Taking the mobile phase provided under the determination of the content of rhubarb medicinal materials in the 2000 edition of "Chinese Pharmacopoeia" as a reference, the experiment selected four mobile phases with different ratios of methanol and 0.1% phosphoric acid solution for investigation, and the ratios were 85:15, 80:20, 78:22, 77:23, the results show that among the four mobile phases with different ratios, methanol: 0.1% phosphoric acid solution (77:23) has the best separation effect, and the sample resolution and tailing factor are in line with Regulation.

experiment example 3

[0028] Experimental Example 3: Preparation of Reference Substance Stock Solution

[0029] Precisely weigh 5.03 mg of emodin reference substance and 4.31 mg of chrysophanol reference substance in a 50ml volumetric flask, add methanol to dissolve and set the volume to the mark, and use it as the reference substance stock solution.

[0030]Accurately measure 1.0ml, 2.0ml 1, 3.0ml, 4.0ml, 5.0ml, 6.0ml of the stock solution respectively, put them in a 50ml volumetric flask, add methanol to dissolve and set the volume to the mark, shake well, and follow the high performance liquid chromatography ( Chinese Pharmacopoeia 2000 edition one appendix VID) measurement, each 10 μ l of above-mentioned solutions are drawn accurately respectively, inject liquid chromatograph, measure peak area (see table 2.2), take concentration as abscissa, peak area as ordinate, get standard curve.

[0031] Concentration (μg / ml)

[0032] It can be seen from the regression equation that within the...

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Abstract

The present invention discloses the quality detection method for Jinzhen oral liquid as one kind of oral liquid for treating infant's lung heat cough. The quality detection method includes the thin-layer chromatographic identification of glycryyhetic acid in licorice, baicalin in skullcap root and the cholic acid component in artificial bezoar, and the content measurement of emodin and chrysophanol components in rhubarb. The said method can used in controlling the quality of Jinzhen oral liquid strictly.

Description

technical field [0001] The invention relates to a quality detection method, in particular to a quality detection method of oral liquid for treating infantile lung-heat cough (Jinzhen oral liquid) Background technique [0002] Jinzhen Oral Liquid is a new drug developed on the basis of the preparation Lingyang Qingfei Powder to remove the taste of cinnabar, and then through reforms in technology and preparation. It is used to treat cough due to lung heat in children. Lingyang Qingfei Powder is a powder. As a medicine for children, it is inconvenient to administer and has a bitter taste, which is difficult for children to accept. The powder is a solid dosage form with poor absorption and cannot quickly exert its curative effect. Therefore, on the basis of investigation and research, integrating modern research methods and research results, using advanced preparation technology to change powder into oral preparations, so that it has the characteristics of fast absorption, good ...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 肖伟戴翔翎凌娅沈静张孝法徐涟明
Owner JIANGSU KANION PHARMA CO LTD
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