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Solid preparation taken through oral cavity of compound MEthoxyphEnaminE and preparation method

A technology of solid preparations and compound methoxy, which is applied in the direction of respiratory diseases, active ingredients of heterocyclic compounds, drug combinations, etc., can solve problems such as poor fluidity of capsule contents, affecting the stability of oral dosage forms, and inconvenience of industrial production

Active Publication Date: 2007-05-09
ADVENCHEN LAB NANJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound methoxyphenamine capsules sold in the market are often unstable because one of the components, methoxyphenamine, is easy to cause moisture and the other component, aminophylline, will escape diethylamine when the moisture, temperature and other conditions change. Thereby affecting the stability of the various oral dosage forms thus obtained, problems such as discoloration of the tablet, poor fluidity of the capsule content, deformation and discoloration of the capsule shell during storage and discoloration of the content occur, which bring problems to practical application and industrialized production. inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of Compound Methoxyphenamine Capsules

[0018] Grind all the raw materials including methoxyphenamine hydrochloride, narcodine, aminophylline, and chlorpheniramine maleate, and take the main drug of compound methoxyphenamine in the conventional prescription amount, namely 25mg aminophylline, 12.5mg formazan hydrochloride Add 3.25 mg of glyceryl behenate to oxypheniramine, 7 mg of narcotin and 2 mg of chlorpheniramine maleate, stir and mix for 50 minutes, then add 50 mg of calcium hydrogen phosphate and 2 mg of micropowder silica gel and mix well. The above mixture is filled in No. 4 capsules to obtain compound methoxyphenamine capsules.

Embodiment 2

[0019] Embodiment 2: Preparation of Compound Methoxyphenamine Capsules

[0020] Grind all the raw materials including methoxyphenamine hydrochloride, narcodine, aminophylline, and chlorpheniramine maleate, and take the main drug of compound methoxyphenamine in the conventional prescription amount, namely 25mg aminophylline, 12.5mg formazan hydrochloride Add 2.56 mg of glyceryl behenate to oxypheniramine, 7 mg of narcotin and 2 mg of chlorpheniramine maleate, stir and mix for 30 minutes, then add 40 mg of calcium hydrogen phosphate and 1.5 mg of micropowder silica gel and mix well. The above mixture is filled in No. 4 capsules to obtain compound methoxyphenamine capsules.

Embodiment 3

[0021] Embodiment 3: Preparation of Compound Methoxyphenamine Capsules

[0022] Grind all raw materials including methoxyphenamine hydrochloride, narcodine, aminophylline, and chlorpheniramine maleate, take the main drug of compound methoxyphenamine in conventional prescription, stir and mix for 55 minutes, and then add 50 mg of hydrogen phosphate Calcium and 1mg micropowder silica gel are mixed evenly. The above mixture is filled in No. 4 capsules to obtain compound methoxyphenamine capsules.

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PUM

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Abstract

An orally-taken composite solide medicine containing methoxyphenamine is prepared from the methoxyphenamine hydrochloride, noscapine, euphyllin, chlorphenamine maleate and diluent chosen from 13 compounds including stearic acid, calcium hydrogen phosphate, microcrystalline cellulose, etc.

Description

technical field [0001] The invention relates to a compound methoxyphenamine oral solid preparation and a preparation method thereof. Background technique [0002] Asthma is the most common respiratory disease, which is caused by various causes such as allergies, circulatory system or lung congestion, bronchial edema, kidney or heart disease, and central nervous system excitement. Compound methoxyphenamine is based on the above-mentioned various causes of disease and with more effective drug ingredients methoxyphenamine hydrochloride (bronchial asthma treatment agent), narcotin (antitussive), aminophylline (cardiac diuretic) and horse Chlorpheniramine hexate (antihistamine) and other asthma treatment agents can effectively alleviate the attack of cardiac asthma or bronchial asthma, suppress cough and various related symptoms. [0003] At present, the compound methoxyphenamine capsules sold in the market are often unstable because one of the components, methoxyphenamine, is e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/522A61P11/06A61P37/08A61K31/4741A61K31/137A61K31/4402
Inventor 周树忠胡雅芳
Owner ADVENCHEN LAB NANJING
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