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Blood stasis dispelling dripping pills for treating coronary heart disease, angina pectoris and hyperlipemia and preparation process thereof

A technology for coronary heart disease angina pectoris and hyperlipidemia, which is applied in the field of traditional Chinese medicine preparations and can solve problems such as dripping pills that have not yet been seen.

Active Publication Date: 2007-08-15
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no drop pill dosage form yet

Method used

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  • Blood stasis dispelling dripping pills for treating coronary heart disease, angina pectoris and hyperlipemia and preparation process thereof
  • Blood stasis dispelling dripping pills for treating coronary heart disease, angina pectoris and hyperlipemia and preparation process thereof
  • Blood stasis dispelling dripping pills for treating coronary heart disease, angina pectoris and hyperlipemia and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0261] prescription:

[0262] Peach kernel (stir-fried) 0.25kg Angelica 0.15kg Citrus aurantium (stir-fried with bran) 0.1kg Chuanxiong 0.075 kg

[0263] Bupleurum 0.05kg, Safflower 0.15kg, Achyranthes bidentata 0.15kg, Radix Paeoniae Rubra 0.18kg

[0264] Rehmannia 0.15kg Bellflower 0.075kg Licorice 0.5kg

[0265] According to the prescription, take 11 herbs to extract 2ml of volatile oil, extract the dregs with water 3 times, add 6 times the amount of water, decoct for 1 hour, filter, dregs ① for later use, combine the filtrates, and concentrate under reduced pressure to a relative Density is 1.16 (measured at 75°C) extract 1.38kg, add ethanol to make the alcohol content 60%, stir evenly, let it stand for 24h to precipitate, take the supernatant to recover ethanol, concentrate under reduced pressure to a relative density of 1.30 (70 0.62kg ② of the clear ointment (measured at ℃), set aside; extract the dregs ① twice with 80% ethanol, add alcohol 7 times respectively, reflu...

Embodiment 2

[0267] prescription:

[0268] Peach kernel (stir-fried) 0.25kg Angelica 0.15kg Citrus aurantium (stir-fried with bran) 0.1kg Chuanxiong 0.075kg

[0269] Bupleurum 0.05kg, Safflower 0.15kg, Achyranthes bidentata 0.15kg, Radix Paeoniae Rubra 0.18kg

[0270] Rehmannia 0.15kg Bellflower 0.075kg Licorice 0.5kg

[0271] Extract the 11 medicinal materials with water twice according to the prescription amount, add 8 times the amount of water respectively, decoct for 1 hour, filter, combine the filtrate, concentrate under reduced pressure to 1.24kg of extract with a relative density of 1.18 (measured at 75°C), Add ethanol to make the alcohol content 70%, stir well, let it stand for 24 hours to precipitate, take the supernatant to recover ethanol, concentrate under reduced pressure to 0.35kg of clear paste with a relative density of 1.30 (measured at 70°C); then use 1 times the amount Extracted 4 times with ethyl acetate, combined the extracts, recovered ethyl acetate, concentrated un...

Embodiment 3

[0273] prescription:

[0274] Peach kernel (stir-fried) 0.25kg Angelica 0.15kg Citrus aurantium (stir-fried with bran) 0.1kg Chuanxiong 0.075kg

[0275] Bupleurum 0.05kg, Safflower 0.15kg, Achyranthes bidentata 0.15kg, Radix Paeoniae Rubra 0.18kg

[0276] Rehmannia 0.15kg Bellflower 0.075kg Licorice 0.5kg

[0277]Extract 11 medicinal materials with 80% ethanol twice according to the prescription amount, add 7 times the amount of ethanol for the first time, decoct for 2 hours, and collect the filtrate; add 5 times the amount of ethanol for the second time, decoct for 1 hour, collect the filtrate, and combine the two secondary filtrate. Then the filtrate was concentrated under reduced pressure to 1.02 kg of extract with a relative density of 1.15 (measured at 70° C.), extracted twice with 1 times the amount of ethyl acetate, and ethyl acetate was recovered, concentrated under reduced pressure to a relative density of 1.20 (70° C.). Determination) clear ointment 0.007kg ①, set...

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PUM

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Abstract

Disclosed is a blood stasis dispelling dripping pills for treating coronary heart disease, angina pectoris and hyperlipemia and preparation process, wherein the drop pills are prepared from matrix of polyethylene glycol 6000, active constituents of peach kernel, Chinese angelica root, bitter orange, Ligusticum wallichii, Bupleurum root, safflower, achyranthes and cyathula root, radix paeoniae rubrathe, dried rehmannia root, root of ballon flower and licorice root. The weight portion of active constituent and matrix is 1:1.8-2.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a Xuefu Zhuyu dripping pill for treating coronary heart disease, angina pectoris and hyperlipidemia and a preparation method thereof. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, the Ministry of Health standard WS 2 -B-0928-91 records the prescription: [0003] Peach kernel (fried) 200g Angelica 150g Citrus aurantium (bran fried) 100g Chuanxiong 75g [0004] Bupleurum 50g, Safflower 150g, Achyranthes bidentata 150g, Radix Paeoniae Rubra 100g [0005] Rehmannia glutinosa 150g Bellflower 75g Licorice 50g [0006] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal resistance, chest pain or headache, internal heat and depression, insomnia and dreaminess, palpitations, irritability and anger. [0007] Preparat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/804A61K36/75A61K36/73A61K36/71A61K36/484A61K36/34A61K36/286A61K36/236A61K36/233A61K36/232A61K36/21A61P9/10
Inventor 朱晓晶马洪波李永仓李凤阁杨静赵喆
Owner TIANJIN HONGRENTANG PHARM CO LTD
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