Application of active biological product in preparing anti HIV medicine
A biological product and active technology, applied in the application field of preparing anti-HIV drugs, can solve the problems of drug resistance, high price, and many side effects
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Embodiment 1
[0024] Embodiment 1: Preparation of active biological products
[0025] After cleaning the soft-shelled turtle for a week, weigh 6kg of the spinal cord, brain, liver and blood mixture of the soft-shelled turtle, mince it, add distilled water at a ratio of 1:6, adjust the pH value to 6.5, heat at 45°C, add neutral protease, and keep warm for enzymatic hydrolysis After 8 hours, refrigerate, suction filter, and centrifuge to obtain the enzymatic hydrolyzate for later use.
[0026] Weigh 0.7 kg of deer penis, enzymatically hydrolyze it as above, or soak it in 80% alcohol solution, refrigerate the extract, filter it, and set aside.
[0027] Mix 28kg of soft-shelled turtle spinal cord, brain, liver, and blood enzymolysis solution and 3.5kg of deer whip extract evenly, add 80g of VC, 40g of VE, 600g of fructose 1.6-diphosphate, and 3.5kg of honey, adjust the pH value after mixing evenly 4. Suction filtration, centrifugation, filling into a 30ml vial, capping, and packaging into boxe...
Embodiment 2
[0028] Example 2 Preparation of active biological products
[0029] Weigh 6kg of the tortoise's spinal cord, brain, liver, and blood mixture, mince it, add distilled water at a ratio of 1:8, adjust the pH value at 6.5, heat at 50°C, add papain, neutral protease, keep warm for 6 hours, and refrigerate , suction filtration, and centrifugation to obtain the enzymatic hydrolyzate, which is set aside.
[0030] Weigh 5.5 kg of seal penis, enzymatically hydrolyze it as above or soak it in 60% ethanol solution, refrigerate, and filter to obtain an extract, which is set aside.
[0031] Mix 40kg tortoise spinal cord, brain, liver, blood enzymolysis solution and 32kg seal whip enzymolysis (extraction) solution evenly, add VB 1 150g, VB 12 180g, 1800g fructose 1.6-diphosphate, 4.5kg honey, dissolve and mix evenly, adjust the pH value to 3.5, suction filter, centrifuge, fill into a 50ml vial, seal, sterilize, and pack into boxes.
Embodiment 3
[0032] Example 3: Effect of active biological products on CD4 cell count and viral load in HIV-infected patients
[0033] 1. Materials and methods
[0034] 1. Case selection and administration method
[0035] Select 10 HIV-infected patients, who were found to be HIV-positive for more than 1 year, have never received HAART treatment, have no opportunistic infections or tumors, and have a CD4 count of 100-300 / mm 3 Between, aged 16-50. Divided into two groups at random, one group was given 30ml of the active biological product of the present invention (prepared according to Example 1), qod, orally, and the other group was controlled without medication, and the course of treatment was 6 months. The treatment group was excluded because one patient started HAART halfway. The basic data of the two groups are shown in Table 1:
[0036] Table 1 Comparison of basic conditions between the treatment group and the control group
[0037] group
therapy group
control gr...
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