Medicine for treating cystic hyperplasia of mammary gland and preparation method thereof

A breast cystic hyperplasia and drug technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of unsuitability for routine use, large side effects, and long medication cycles, and achieves good analgesic effects, Strong effect of dispersing and removing blocks

Active Publication Date: 2007-08-22
广东泰康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs for treating cystic hyperplasia of the breast are multi-purpose sex hormones in Western medicine, including antihormonal drugs tamoxifen, androgen drugs and prolactin drugs, but these drugs have disadvantages such as large side effects, long medication cycle, and not suitable for routine use.
Western medicine treatment of cystic hyperplasia of the breast also adopts surgical methods, but due to well-known reasons, surgery is not easily accepted by patients
At present, traditional Chinese medicines for the treatment of cystic hyperplasia of the breast include Asparagine Tablets, Xiaohe Tablets, Rupixiao...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1, the present invention treats the preparation of breast cystic hyperplasia medicine

[0046] Drugs for the treatment of breast cystic hyperplasia, the prescription of which is as follows: Bupleurum 125g, Chishao 250g, Prunella vulgaris 300g, Oyster 300g, Angelica 250g, Tianqi 250g, Codonopsis 200g, Qingpi 125g, Tangerine core 200g, Shepherd’s purse 200g, Leulu 200g, Guijianyu 150g, Wangbuliuxing 200g.

[0047] The method for preparing the medicine for treating breast cystic hyperplasia comprises the following specific steps:

[0048] 1) Weigh the components in the above prescription, and perform routine pretreatment;

[0049] 2) Crush Bupleurum, Angelica, Leulu and Qingpi into coarse powder, then add it to water six times the total weight of Bupleurum, Angelica, Leulu and Qingpi, and distill for 5 hours to obtain about 1.2 g of volatile oil;

[0050] 3) β-CD cyclodextrin (or methyl cyclodextrin, hydroxypropyl cyclodextrin, hydroxyethyl cyclodextrin, cyclo...

Embodiment 2

[0058] Embodiment 2, the experiment that the medicine of the present invention treats cystic hyperplasia of mammary glands influences on estradiol benzoate mammary gland hyperplasia model rats

[0059] Adopt the medicine for the treatment of cystic hyperplasia of mammary glands prepared by embodiment 1 (clinical experiment is named as Chashao Ruhexiao tablet), carry out animal experiment to estradiol benzoate hyperplasia of mammary gland model rat, by contrast experiment, investigate medicine of the present invention to Therapeutic effects in rats with mammary gland hyperplasia. The specific experimental process is as follows:

[0060] Take 60 SD rats, female, with a body weight of 199.2±11.9g, and randomly divide them into 6 experimental groups, including the normal control group and the model control group. g / Kg, 11.88g / Kg three groups, Rupixiao tablet group administration dose is 1.04g / Kg group, each group of experimental rats 10.

[0061] Rats in the normal control group...

Embodiment 3

[0108] Embodiment 3, the experiment that the present invention treats cystic hyperplasia of mammary gland to the influence of qi stagnation and blood stasis model rats

[0109] Adopt the medicine for the treatment of cystic hyperplasia of mammary glands prepared by embodiment 1 (clinical experiment named as Chashao Ruhexiao tablet), carry out animal experiments to Qi stagnation and blood stasis model rats, by contrast experiment, investigate medicine of the present invention to test rats therapeutic effect. The specific experimental process is as follows:

[0110] Take 60 SD rats, female, with a body weight of 203.4±14.5g, and randomly divide them into 6 experimental groups, including the normal control group and the model control group. Three groups of Kg and 11.88g / Kg, the dosage of Rupixiao tablet is 1.04g / Kg group, each group has 10 experimental rats. Except for the normal control group, the other animals were fed with 200% rhubarb decoction 20ml / Kg. One hour later, the ...

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Abstract

The invention relates to a medicament for treating hyperplasia of mammary glands and its preparing process, wherein the medicament is prepared from the following raw materials (by weight portions): bupleurum root 0.8-1.2, red peony root 1.8-2.2, selfheal 2.2-2.6, oyster 2.2-2.6, Chinese angelica root 1.8-2.2, notoginseng 1.8-2.2, root of pilose asiabell 1.4-1.8, green tangerine orange peel 0.8-1.2, tangerine seed 1.4-1.8, capsella 1.4-1.8, globe thistle 1.4-1.8, winged euony twigs 1.0-1.4, seed of cowherb 1.4-1.8.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a medicine for treating breast cystic hyperplasia and a preparation method thereof. Background technique [0002] Hyperplastic disease of breast HDB (Hyperplastic disease of breast HDB) is a proliferative breast disease that is neither inflammation nor tumor. It belongs to the category of "breast addiction" and "breast tuberculosis" in traditional Chinese medicine. Its incidence rate accounts for about 40% of women of childbearing age, ranking first among women's breast diseases, accounting for about 60% to 70% of them. Cystic hyperplasia of the breast is mainly manifested as breast tenderness and lumps, and has the characteristics of changing with menstrual cycle or emotional changes, which seriously endangers the physical and mental health of young and middle-aged women, and increases the risk of breast cancer. Cystic hyperplasia of the breast ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/71A61K36/536A61K36/37A61K36/36A61K36/344A61K36/31A61K36/28A61K36/258A61K36/233A61K36/232A61K35/56A61K9/28A61P15/14
Inventor 张军兵蔡光先卜献春史官正余家相汪平武惠斌
Owner 广东泰康制药有限公司
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