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Antimicrobial/endotoxin neutralizing polypeptide

A technology for antimicrobial polypeptides, endotoxins, applied in the field of truncated forms, similar ones, endotoxin-neutralizing polypeptides or functional variants thereof, by administering the polypeptides of the present invention together with antimicrobials

Inactive Publication Date: 2002-08-07
EJINEX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these studies did not provide any evidence that the peptide has antimicrobial or endotoxin neutralizing activity

Method used

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  • Antimicrobial/endotoxin neutralizing polypeptide
  • Antimicrobial/endotoxin neutralizing polypeptide
  • Antimicrobial/endotoxin neutralizing polypeptide

Examples

Experimental program
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Effect test

Embodiment

[0079] Host defense polypeptides that produce LF in vivo

[0080] LF is unusually resistant to proteolysis (R.D. Brines and J.H. Brock, Biochim. Biophys. Acta 759:229-35 (1983)), and little is known about its processing during inflammation in vivo. Therefore, N-terminal regions present as small (eg <12 kDa) polypeptides in inflamed human tissue were examined. Immunoblots of sputum from individuals with deep bronchial cough and purulent exudates ("pus") obtained from infected human skin were probed with antibodies specific for the N-terminal 17 residue of mature human LF. The N-terminal region of LF was identified as a low molecular weight polypeptide (Mr-6,000-8,000) in all tested secretions. Scanning density comparison of the immunostaining intensity of the sample 6kDa polypeptide with that of the standard indicated that the fragment was present in secretions at 1-10 [mu]M. This N-terminal polypeptide was also detected in human sputum, although not in gingival plaque or hum...

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Abstract

The present invention provides a therapeutic method for treating or preventing a disease resulting from a microbial infection in an individual using an antimicrobial polypeptide. The present invention also provides a method of potentiating the therapeutic action of an antimicrobial drug in a patient. Further provided in the present invention are methods for neutralizing circulating endotoxin in a patient by administering the endotoxin-neutralizing polypeptide or functional variant thereof of the present invention to the patient.

Description

Background of the Invention [0001] Although humans are constantly at risk of infection by microbial pathogens, most have withstood the repeated onslaught of these pathogens by rapidly developing responses utilizing a variety of antimicrobial proteins and small peptides. Because primitive animals, insects, and even plants also utilize antimicrobial peptides, this branch of the human innate immune system represents a more fundamental host defense mechanism than the slower-acting asexual reproduction system (H.G. Boman, J. Marsh, and J.A. Goods Ed., "Antimicrobial Peptides", (John Wiley & Sons Ltd., New York, NY, 1994); Hoffmann et al., Curr. Opin. Immunol. 8:8-13 (1996)). [0002] In addition to inhibiting the growth of microbial pathogens, the immune system can neutralize various toxins produced by invading microorganisms. A type of toxin produced by Gram-negative bacteria is called endotoxin. Endotoxins (lipopolysaccharides; LPS) are constituents of the outer membrane of Gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A23L3/3526A23L5/20A61K31/4409A61K31/496A61K38/00A61P31/00A61P31/04A61P31/06A61P31/08C07K14/79C07K19/00C12N5/00
CPCC07K14/79C07K2319/00A61K38/00A61P31/00A61P31/04A61P31/06A61P31/08
Inventor D·M·曼
Owner EJINEX
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