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Cartilage tissue engineering scaffold composite material

A composite material and cartilage tissue technology, applied in the field of bone materials, can solve problems such as long degradation time, easily deformed plant cells, damage, etc.

Inactive Publication Date: 2002-11-20
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these materials can meet the basic requirements of cartilage tissue engineering preparation technology in some aspects, they all have defects such as low elastic modulus, easy deformation under stress, which leads to damage of implanted cells, and long degradation time.

Method used

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  • Cartilage tissue engineering scaffold composite material
  • Cartilage tissue engineering scaffold composite material
  • Cartilage tissue engineering scaffold composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] A CPPf / PLLA(50 / 50) cartilage tissue engineering scaffold composite material was prepared.

[0017] The PLLA1.0g that average molecular weight is 100,000 is dissolved in the chloroform solvent of 10ml, and the PLLA solution that makes concentration is 10%; Add the CPPf1.0g that length is 10mm, and stir, obtain CPPf / PLLA (50 / 50) solution; then add 18.0g of Nacl particles with a particle size of 100-300um, stir evenly and pour into a mold for casting; the molding is demoulded after natural volatilization at 20-30°C for 56 hours, and then vacuumed at a degree of 1×10 -3 Vacuum in a vacuum desiccator in Torr for 24 hours to remove residual chloroform in the molded product; soak the molded product in secondary distilled water for 72 hours, during which the distilled water is replaced every 6 hours, and then dried at room temperature for 24 hours hours, and finally vacuum-dried for 48 hours to prepare a high-porosity CPPf / PLLA (50 / 50) cartilage tissue engineering scaffold com...

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Abstract

The present invention uses L-lactic acid polymer whose molecular weight is 80000-200000 and calcium polyphosphate fibre whose mean length is 5-15 mm and adopts dissolving casting granule leaching process to obtain the invented skeleton material capable of being transplanted in the body. As compared with tissue engineering scaffold material of existent technology said invented product possesses high voidage, good biological degradable property and physical mechanical property, and possesses three-D communication, micropore and reticular microstructure, so that it can completely meet the basic requirements for tissue engineering.

Description

1. Technical field [0001] The invention belongs to substitutes or substitutes for various parts of the human body, in particular to bone materials that can be transplanted into the body. 2. Background technology [0002] Cartilage defects and dysfunctions caused by trauma or other diseases are very common in clinical medicine. In recent years, with the emergence of tissue engineering, it has brought opportunities for the complete regeneration and repair of cartilage defects. The biodegradable and absorbable three-dimensional interconnected microporous scaffold material plays a very important role in tissue engineering. It is a place for cell planting and a template for tissue regeneration. The basic requirements for this scaffold material are: (1) have a good Biocompatibility, (2) The porosity is not less than 90%, (3) The surface can allow cells to adhere and grow, (4) The material can gradually degrade and absorb during the process of cell growth, reproduction and tissue ...

Claims

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Application Information

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IPC IPC(8): A61L27/44C08J9/26
Inventor 戴刚石宗利李起鸿李重庵
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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