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Preparation process of spinal cord and peripheral nerve repairing material

A technology for peripheral nerves and repair materials, applied in catheters and other directions, can solve problems such as chaotic and irregular diameters of tubes and directions of canal gaps, inability of regenerative fibers to grow in an effective direction, and effects on treatment or experiment effects, etc.

Inactive Publication Date: 2002-11-20
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The internal structure of the matrix carrier material developed in the past is chaotic and irregular in the size of the tube diameter and the direction of the canal space, so that the regenerative fibers after the spinal cord or peripheral nerve segmental injury cannot effectively grow in a direction, thus seriously affecting the effect of treatment or experiment

Method used

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  • Preparation process of spinal cord and peripheral nerve repairing material
  • Preparation process of spinal cord and peripheral nerve repairing material
  • Preparation process of spinal cord and peripheral nerve repairing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: see figure 1 , according to the technical scheme of the present invention, taking type I collagen and chondroitin sulfate-6 as an example, its preparation method is carried out according to the following steps:

[0022] 1) During production, dissolve type I collagen at 27.5mg / ml in 0.05M (acetic acid, hydrochloric acid, etc., the same below) acidic solution, and stir at 2000r / min for 90min at a constant temperature of 4°C to 10°C , made into a suspension;

[0023] 2) Add chondroitin sulfate-6 at 1.33mg / ml into 0.05M acidic solution, and stir at 2000r / min for 90min at a constant temperature of 4°C to 10°C to make a suspension;

[0024] 3) Mix the two suspensions at a ratio of 5:1, and continue to stir at 2000r / min for 90 minutes at 4°C to 10°C to make a mixed suspension of collagen and chondroitin sulfate-6, and make the suspension The solution was placed in a long-necked flask, vacuumed and left for 30 minutes to eliminate foam;

[0025] 4) Inject the m...

example 2～6

[0042] The following examples 2-6. The mixing ratio of collagen (type I, III, IV) and aminoglycan (chondroitin sulfate-6 or chondroitin sulfate-4) is the same.

Embodiment 2

[0043] Example 2: Prepared by using type III collagen and chondroitin sulfate-6 as raw materials. Its implementation process is with embodiment 1.

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Abstract

The new-type spinal cord and peripheral nerve repairing material possesses same-direction microtube type structure characteristics, and can be made into the forms of cylinder and rectangle according to the requirements. It has the following characteristics: 1. exteral surface of said material is full-closed structure, can effectively preventing internal fibre connective tissue from growing into; 2. the microtube diameter size of the material can be controlled in 30-200 micrometers, it is favorable for growth of nerve regenerative fibre; and 3. arrangement directions of microtubes are axial, and mutual parallel and uniform. it is favourable of directional extension of nerve regenerative fibre. It can be dirctly implanted for repairing spinal cord and peripheral nerve defect, also can be used as carrier of various cell implantation, can carry various nerve growth factors and nerve trunk cell, etc.

Description

[0001] 1. Field [0002] The present invention relates to the preparation of a material that can be used in the treatment of human body after trauma or animal experiment research in the field of medicine, in particular to a material made of collagen and aminoglycans for bridging peripheral nerve or spinal cord segmental injuries The preparation technology of spinal cord and peripheral nerve repair materials with microtubular structure characteristics in the same direction. 2. Background technology [0003] It is known that the extracellular matrix contains three major categories: collagen, aminoglycans, and glycoproteins. Collagen and aminoglycans not only endow the body with physical characteristics and provide a scaffold for various cells throughout the body, but also have a profound impact on the biological functions of these cells. It has the functions of cell adhesion, signal transmission between cells, migration and binding with fibronectin, laminin, vitronectin and col...

Claims

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Application Information

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IPC IPC(8): A61L29/04
Inventor 罗卓荆章庆峻
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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