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Aqueous pharmaceutical compositions

A composition and drug technology, applied in the field of water-based pharmaceutical composition, can solve the problems of dispersed dosage and difficulty in constant dosage, and achieve the effects of fast gelation speed, low gelation temperature and high utilization efficiency

Inactive Publication Date: 2003-10-01
WAKAMOTO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the viscosity of the formulation is increased, the problem of dispersion of the dosed amount arises, and this disadvantage makes constant dose administration difficult

Method used

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  • Aqueous pharmaceutical compositions
  • Aqueous pharmaceutical compositions
  • Aqueous pharmaceutical compositions

Examples

Experimental program
Comparison scheme
Effect test

test example 19

[0287] [Intraocular pressure-lowering effect of thermal gel preparation containing isopropyl unoprostone]

[0288]

[0289]Mix SM-4 (2.3g) and Macrogol 4000 (2.0g), then add 70mL of sterilized distilled water heated to 85°C, and stir to disperse these components. After confirming that these components are uniformly dispersed, use ice while stirring. The dispersion is cooled. After confirming that the whole solution becomes clear, gradually add 3.53 g of sodium citrate, and stir to dissolve. 1N HCl was added thereto to adjust the pH to 6.5, and then sterilized distilled water was added to a volume of 100 mL to prepare a thermogelling matrix. Separately, 50 mL of Rescula (registered trademark) eye drops (manufactured by Uenoseiyaku Corporation) were freeze-dried. 50 mL of the aforementioned thermogel base was added thereto, and these components were stirred and dissolved while cooling with ice to prepare an isopropyl unoprostone-containing thermogelling preparation.

[0290...

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PUM

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Abstract

The object of the present invention is to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when containing a new quinolone antibacterial preparation such as ofloxacin as an active ingredient. , and although they are liquid when administered, they can remain at the site of administration for a long time due to a rapid increase in viscosity after administration, thus obtaining agents with high drug utilization efficiency. The present invention relates to an antibacterial aqueous pharmaceutical composition. The composition contains: 2.8-4w / v% methylcellulose, the viscosity of its 2w / v% aqueous solution at 20°C is 12mPa.s or lower; 1.5 -2.3w / v% citric acid; 2-4w / v% polyethylene glycol and 0.1-0.5w / v% ofloxacin.

Description

technical field [0001] The present invention relates to an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when containing a new quinolone antibacterial agent such as ofloxacin as an active ingredient, and despite They are liquid when administered, but due to the rapid gelation rate resulting in a rapid increase in viscosity after administration, they are able to remain at the site of administration for a long period of time, thus obtaining a high utilization efficiency of the medicament. Background technique [0002] Since most of the drug flows from the eye to the nose when the drug is administered to the eyes, studies have been made to allow the drug to stay on the surface of the eye for as long as possible by increasing the viscosity of the formulation. In order to increase the viscosity of the formulation, polymeric compounds are usually added. However, when the viscosity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/00A61K31/5383A61K47/00A61K47/10A61K47/12A61K47/38A61P27/02A61P31/04
CPCA61K9/0048A61K31/5383A61K47/10A61K47/12A61K47/38A61P27/02A61P31/04
Inventor 铃木秀一和田敬弘切田雅信武内正史
Owner WAKAMOTO PHARMA
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