Derivant of new type sweetsop lactone as well as preparation method and usage

Abstract

A novel annonaceous acetogenin derivative used for treating cancer and preventing and eliminating diseases and pests of agricultural crops is prepared through extracting from annonaceous plant and separation, or chemical synthesis.

Description

technical field [0001] The invention relates to a novel annona lactone derivative, further relates to its preparation method, and further relates to its use in cancer treatment and agricultural disease and insect pest control. Background technique [0002] Annonaceous acetogenins are a kind of long-chain fatty acid γ-lactone derivatives unique to some plants of Annonaceae. The structural characteristics of this kind of substance are: there is a methyl-substituted α, β-unsaturated γ-lactone ring at one end of a long fatty chain, 1-3 tetrahydrofuran rings and other oxygen-containing substituents on the fatty chain , such as hydroxyl, acetoxy, ketone, epoxy, etc., and carbon-carbon double bonds. In recent years, some tetrahydropyran ring and tetrahydrofuran ring-free annona lactone derivatives have also been discovered. Annonaceolide compounds have been paid attention to because of their strong biological activity. In 1988 and 1989, Mikolajczak et al. obtained two invention ...

AI Technical Summary

Problems solved by technology

In the structural patterns of these patented compounds, there are tetrahydrofuran rings, many chiral centers, and complex structures, which are difficult to chemically synthesize. Therefore, people have carried out a lot of researches based on the structure-activity relationship of the annona lactone compound. Simplify Synthetic Research

In China, Wu Yulin and others removed the carbon bridge of the tetrahydrofuran ring and retained the ether oxygen group, and successively synthesized two kinds of non-THF ring-type annona lactone derivatives with anticancer activity, but the structure is relatively complicated (CN97106368.0; CN99125750.2)

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