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Method for synthesizing artificial bone from carboxylic apatite of coral

A technology of coral hydroxyapatite and hydroxyapatite, which is applied in the field of artificial bone, can solve the problems of no public reports on the preparation process, and achieve good bone defect fusion, good biocompatibility, and good bone healing

Inactive Publication Date: 2003-12-24
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There have been some reports in the literature on the use of natural mineral material coral as raw material to modify and synthesize hydroxyapatite (CHA) artificial bone, but there is no public report on its specific preparation process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Take 50g (block) of natural mineral material coral and cut it into three pieces of 1×1×1cm, 2.8×1.2×1.5cm, 6.3×1.5×0.65cm on a diamond cutter, weighing 19.0g.

[0042] 2. Place the three cut raw material samples in a beaker filled with deionized distilled water, and clean them in an ultrasonic cleaner.

[0043] 3. Design the synthetic experimental conditions, the pressure is 100×10 5 Pa, the temperature is 220°C, and the synthesis is carried out in an autoclave. Calculate according to the volume of the raw material sample, and the filling degree of the added medium liquid is 0.75, and calculate the amount of the medium solution to be added according to the filling degree.

[0044] 4. The medium is a saturated aqueous solution of diammonium hydrogen phosphate, the concentration is 3M, and the pH of the solution is 8.5 when measured with a pH meter.

[0045] 5. Put the raw material samples and the medium solution into the autoclave together, and place the sealing plug...

Embodiment 2～6

[0059]Synthetic process with reference to Example 1. The process condition parameters used in each embodiment, the chemical composition and pore parameters of the obtained CHA artificial bone products are shown in Table 2 to Table 4 respectively.

[0060] Table 2 Examples of different temperature and pressure conditions for the synthesis of CHA artificial bone Raw material Weight Medium composition Concentration Before reaction Temperature Pressure Reaction time After reaction Product number (g) (M) pH (°C) (×10 5 Pa) (hours) pH2 Porites (NH 4 ) 2 HPO 4

[0061] (CaCO 3 ) 35 +H 2 O 3 8.3 280 500 168 8 CHA Artificial Bone 23 Porites 5 Ditto 2.5 8 400 2500 192 7.8 CHA Artificial Bone 34 Porites 5 Ditto 3.5 8.5 200 100 288 8 CHA Artificial Bone 45 Porites 8 Ditto 3 8.5 270 300 240 8 CHA Artificial bone 56 Porite 21 Same as above 3.5 8.5 200 200 360 8 CHA artificial bone 6

[0062] Table 3 Chemical composition of human bone, raw mater...

Embodiment

[0064] Sample name CaO P 2 o 5 Fe 2 o 3 Na 2 O TiO 2 SrO SiO 2 Ag 2 O NiO CoO MgO SO 2 K 2 O 总数编号对照2a 人骨a 64.85 29.95 0.39 1.87 0.13 0.88 1.26 0.37 99.7对照1a 滨珊瑚a 98.3 1.25 0.59 100.14 2 CHA人工骨2 63.37 35.69 0.22 0.07 0.03 99.4 3 CHA人工骨3 53.25 46.30 0.08 0.10 0.20 0.07 100 4 CHA Artificial bone 4 58.91 41.09 100 5 CHA artificial bone 5 53.13 46.48 0.20 99.81 6 CHA artificial bone 6 64.09 35.52 0.38 99.99

[0065] The electron microscope energy spectrum component analysis results of Table 3 show that the CaO and P of the CHA artificial bone synthesized by the method of the present invention under different temperature and pressure conditions 2 o 5 The content is similar to that of human b...

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Abstract

An artificial coral hydroxy apatitis (CHA) bone for medical purpose is prepared from coral through hydrothermal reaction in the diammonium hydrogen phosphate plus hydrothermal liquid system under high-temp and high-pressure condition to convert the CaCO3 of coral to Ca5(PO4)3(OH) which is just the artificial bone. Its advantages are high compression strength, high porosity (24.86-65.71%), no toxic by-effect and good biologic compatibility.

Description

technical field [0001] The invention relates to an artificial bone for orthopedic medical treatment, in particular to a method for synthesizing a coral hydroxyapatite (CHA) artificial bone. Background technique [0002] Bone defect is a common problem in orthopedics. Bone fusion is a commonly used method in orthopedics. Every year in my country, thousands of people are amputated or resected to disability due to comminuted fractures or osteonecrosis caused by various industrial injuries, car accidents, and accidents. Synthetic Artificial bone grafts can repair damaged limbs of patients, free them from disability and relieve their pain. The preparation of an ideal synthetic artificial bone is a major problem that the orthopedic medical community is eager to solve. [0003] The hotspots and main contents of bone tissue engineering research focus on several aspects: seed cells, scaffold materials, and bioactive factors. Among them, the scaffold material is a very important part...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12C01B25/32
Inventor 李兆麟李文薄遵昭尹庆水张余
Owner SUN YAT SEN UNIV
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