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Method for preparation of artificial bone antigen for biological origin

A bio-derived, artificial bone technology, applied in the field of active bio-derived artificial bone materials

Inactive Publication Date: 2003-12-31
北京市创伤骨科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to overcome the respective defects in the above-mentioned methods, the present invention provides a method for preparing biogenic artificial bone without antigens, which not only helps to make up for the shortcomings of several methods, but also helps to better reduce allogeneic bone Immunogenicity of bone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Make the biogenic artificial bone block into the desired size

[0025] 2. Use anionic surfactant: 1%-70% sodium alkylbenzene sulfonate (ABS) and 1%-80% fatty alcohol polyoxyethylene ether sodium sulfate (AES) to make a total concentration of 50% degreasing liquid

[0026] 3. Soak the bones to be treated in the prepared degreasing solution

[0027] 4. Ultrasonic vibration washing or stirring at a temperature of 20-60°C and a power of 60%-100% for 24-240 hours

[0028] 5. Shake and wash with triple distilled water for 10-20 times

[0029] 6. Freeze-drying for 2-200 hours

[0030] 7. Vacuum packaging, nuclide radiation or ethylene oxide sterilization

Embodiment 2

[0032] The present embodiment differs from Example 1 in that the configuration of the degreasing solution is made with a ratio of 1%-10% nonionic surfactant and 1%-90% anion, cation, and zwitterionic surfactant. The total concentration is 60% degreasing fluid. Other steps are the same as above.

Embodiment 3

[0034] The difference from the previous two embodiments is also the configuration of the degreasing solution, which is made of a total concentration of 40% with 1%-90% zwitterionic surfactant and 1%-90% anion, cation, and zwitterionic surfactant. % degreasing solution. Other steps are the same as above.

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Abstract

Biogenous artificial bone tissue is set inside the solution of serial surfactants for full wetting and penetration, the solution enters to the bone tissue and the fat tissue falls down to disperse inthe surfactant solution and to be eliminated via water rinsing. The surfactant used may be biodegraded inside body and is non-toxic and harmless. The said process has high defatting effect and efficient antigenicity reducing effect. The processed artificial bone has even high mechanical performance, the production process has no pollution, and the product has no residual toxic matter and is convenient in storing and transportation.

Description

Technical field: [0001] The invention relates to the technical field of active biogenic artificial bone materials for bone transplantation in medical orthopedic surgery, in particular to a method for preparing biogenic artificial bone without antigens. Background technique: [0002] As we all know, bone grafting is one of the most commonly used treatment methods in orthopedics for the treatment of bone defects and the reconstruction of bone joints due to loss after trauma, and there are many types of materials used for bone grafting. Among them, active bio-derived artificial bone is the most clinically used material for bone transplantation due to its physical and chemical properties, spatial structure and functional adaptation. The key to the success of the transplantation lies in the immune response of the active biogenic artificial bone after transplantation. The immune response is caused by the antigen in the biogenic artificial bone. How to remove the antigen to reduce ...

Claims

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Application Information

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IPC IPC(8): A61L27/36
Inventor 孙磊田伟尹大庆王戈平黄啸原陈磊高新生杰永生陶剑峰禇黎刘竟成
Owner 北京市创伤骨科研究所
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