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Method for specific adsorption of low density fat-cholesterine in hyperlipemia

A specific, cholesterol-based technology, applied in the field of improvement of heparin in vitro precipitation method, can solve the problems of complex steps and long adsorption reaction process, and achieve the effects of saving reaction time, improving economic and social benefits, and reducing costs.

Inactive Publication Date: 2004-04-14
NANJING RED CROSS BLOOD CENT +1
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Problems solved by technology

Before reinfusing defatted plasma into the body, there must be a desalination and dehydration process. Therefore, the adsorption reaction process is long and the steps are complicated.

Method used

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Experimental program
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Embodiment Construction

[0014] In this example, the water-insoluble carrier used in the adsorbent I coupled with the heparan carrier is 200 mesh glass microspheres, and vinyltriethoxysilane [CH 2 =CHSi(OC 2 h 5 ) 3 ] is a coupling agent, generates adsorbent I through heating and dehydration (such as using cellulose particles as a carrier, then using epichlorohydrin as a coupling agent), and coupling heparin (sulfonated dextran) on every gram of glass beads sugar) 50mg. Use macroporous resin D002 (Jiangyin Organic Chemical Factory, Jiangsu) as a carrier, inject divalent calcium ions to generate adsorbent II, and graft 300 mg of divalent calcium ions on each gram of microspheres for use.

[0015] Its reaction steps are as follows:

[0016] 1) Collect 500ml of high-fat plasma and place it in a lipid plasma collector, put 50g of adsorbent I and 15g of adsorbent II, and shake gently at room temperature for 10 minutes;

[0017] 2) Place the above plasma in a large-capacity centrifuge, centrifuge at 30...

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Abstract

The invention is a method to peculiarly absorb low-density fat-cholesterin in high-fat blood plasm. The absorption is completed by water-insoluble carrier coupled with heparin as sorbentó±and water-insoluble carrier graft bivalent cation as sorbentó�. The reaction steps: 1) adding sorbentó±, 5-10g and sorbentó�3-5g in each 100ml of blood plasm in lipid blood plasm collector to shake lightly for 10-15 minutes under room temperature; 2) placing on high-capacity centrifuger to centrifuge for 10-20 minutes at 2000-3500rpm, and collecting clear defatted blood plasm; 3) using lipid filter to eliminate floating lipid suspension substrate in the clear defatted blood plasm; 4) absorbing excessive bivalent cation to adjust blood calcium to normal physiological concentration.

Description

Technical field: [0001] The invention relates to a method for removing low-density fat-cholesterol (LDL-C) in high-fat plasma, which is an improvement on the original method for removing LDL-C in high-fat plasma-heparin extracorporeal precipitation (HELP). Background technique: [0002] LDL-C is the main pathogenic factor in hyperlipidemia, and a large amount of data has proved that a large increase in LDL-C in the blood can cause cardiovascular diseases and blood circulation disorders in the body. Such as atherosclerosis, cerebrovascular obstruction, dizziness and movement disorders. At present, many scholars have researched a variety of ways to remove LDL-C in hyperlipidemia plasma. Among them, the heparin in vitro precipitation method developed by B. Braun Company in Germany is the most mature technology, the most widely used clinically, and the most treated patients. [0003] Although the heparin precipitation method in vitro is a mature technology, because the heparin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34A61M1/38
Inventor 邹元国孙启俊李爱华
Owner NANJING RED CROSS BLOOD CENT
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