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Salt of organic acid of cyclorrirobuxin-D, pharmaceutics and application as well as its preparation method

A technology of cyclovirboxicin and organic acid salts, applied in the preparation of cyclovirboxicin D organic acid salts, applications and preparations, cyclovirboxicin D organic acid salts and their preparations, can solve the problem of slow oral onset, Problems such as long time to peak blood drug

Inactive Publication Date: 2004-08-11
曹明成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its oral effect is slow, and the blood drug reaches its peak time for a long time. It is mostly used in mild to moderate patients in clinical practice. Therefore, it is widely welcomed by doctors for acute and severe patients and patients with dysphagia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0056] Preparation of Huowei Buxusing D (Huangyangning) Glucose Injection

[0057] 1. Prescription:

[0058] Cyclovitamin D 20mg

[0059] Glucose 50g

[0060] Citric acid or tartaric acid or lactic acid or succinic acid and methanesulfonic acid in moderation

[0061] Add water for injection to 1000ml

[0062] 2. Preparation process

[0063] 1. Preparation: Infusion bottles, rubber stoppers, and polyester liners are processed as usual and put in reserve; pipes and containers are cleaned and put in reserve.

[0064] 2. Take glucose, add water for injection to 1 / 5 of the full amount, add activated carbon (2 / 10,000 g / ml) and boil for 15 minutes, filter out the activated carbon, pump it into the dilute preparation tank, and weigh the prescribed amount of Cyclovir buxylus D Add a small amount of water for injection, add citric acid or tartaric acid or lactic acid or succinic acid and methanesulfonic acid to dissolve completely, add water for injection to the full amount, add ac...

example 2

[0071] The preparation method of Huowei Buxicine D (Huyangning) Sodium Chloride Injection

[0072] 1. Prescription:

[0073] Cyclovitamin D 20mg

[0074] Sodium chloride 9.0g

[0075] Citric acid or tartaric acid or lactic acid or succinic acid and methanesulfonic acid in moderation

[0076] Add water for injection to 1000ml

[0077] 2. Preparation process

[0078] 1. Prepare

[0079] After the routine treatment of the pipes and appliances used for liquid preparation, they should be washed with water for injection; the infusion bottles, rubber stoppers, and polyester liners should be treated according to the usual procedures and set aside for later use.

[0080] 2. Dosing

[0081] [1] Take the prescribed amount of sodium chloride, add water for injection to 1 / 5 of the total amount, stir to dissolve, add 0.02% (w / v) activated carbon for needles at the same time, stir evenly, boil for 15 minutes, and dissolve it with a diameter of 0.8 μm Microporous membrane filtration, s...

example 3

[0089] The preparation method of cyclovirboxine hydrochloride for injection

[0090] 1. Prescription:

[0091] Cyclovitamin D 2.0g

[0092] Mannitol 100g

[0093] Citric acid or tartaric acid or lactic acid or succinic acid and methanesulfonic acid in moderation

[0094] Add water for injection to 2000ml

[0095] A total of 1000 bottles were made

[0096] 2. Preparation process

[0097] Aseptic operation: Take cyclovir buxicine D according to the prescription, put it in a container, add a small amount of water for injection to make a paste, add citric acid, tartaric acid, lactic acid, succinic acid and methanesulfonic acid, stir to dissolve; add the prescription The amount of mannitol, add water for injection to 1600ml; use citric acid or tartaric acid or lactic acid or succinic acid and methanesulfonic acid to adjust the pH value of the solution to 3.5-6.5, add 2g of activated carbon for injection, stir for 10-15 minutes, No. 3 The sand core funnel is used for coarse fi...

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PUM

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Abstract

An organic acid salt of cyclovirobuxine D in the form of injection for treating cardiovascular and cerebrovascular diseases including coronary heart disease, arrhythmia, etc. is prepared from the cyclovirobuxine D, citric acid or tartaric acid or lactic acid or butanedioic acid or methanesulfonic acid, and glucose or sodium chloride or mannitrol.

Description

technical field [0001] The invention belongs to a new traditional Chinese medicine, and the invention relates to an organic acid salt of cyclovir buxicine D and its preparation, application and preparation method of the preparation. More specifically, the present invention relates to an organic acid salt of cyclovirboxicine D, and injections containing them, its preparation method and application. Background technique [0002] Coronary heart disease is a common cardiovascular disease and one of the most important diseases affecting human health. The incidence of coronary heart disease increases with age. It is a common and frequently-occurring disease in the middle-aged and elderly people. In recent years, with the acceleration of the pace of social life and changes in diet structure, cardiovascular diseases such as coronary heart disease have become the number one killer of human health, and it is urgent to choose appropriate drugs for treatment. [0003] Cycloviral Buxaxi...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61P9/06A61P9/10A61P29/00C07J53/00
Inventor 曹明成
Owner 曹明成
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