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Use of compound red-rooted salvia drop pills in preparation of mass cell degranulation prohibiting drug

A technology of compound danshen and mast cells, applied in the field of medicine, can solve the problems of improving microcirculation, etc.

Inactive Publication Date: 2004-08-25
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are reports on the improvement of microcirculation by compound danshen dripping pills, the improvement of microcirculation is the result, and no one or several links or targets are used to improve microcirculation. A report of bolus inhibiting mast cell degranulation and improving microcirculation

Method used

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  • Use of compound red-rooted salvia drop pills in preparation of mass cell degranulation prohibiting drug
  • Use of compound red-rooted salvia drop pills in preparation of mass cell degranulation prohibiting drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 The inhibitory effect of Compound Danshen Dripping Pills on rat mesenteric mast cell degranulation before administration of ischemia-reperfusion

[0012] (1) Experimental method

[0013] 1. Test group and control group

[0014] (1) Normal control group: without ischemia-reperfusion treatment.

[0015] (2) Ischemia-reperfusion group: After 10 minutes of basic observation, the mesenteric arteries and veins still flowing in the observation part were simultaneously ligated with 4G polyethylene tube for 10 minutes (ischemia), and the ligation was released (reperfusion). Set the time recorder to 0. Continuously observe at the same field of view for 30 minutes.

[0016] (3) Compound Danshen dripping pill administration group: 60 minutes before ischemia-reperfusion, compound Danshen dripping pills were dissolved in normal saline at a dose of 0.4 g / kg, and administered intragastrically once.

[0017] (4) Danshen intravenous administration group: 10 minutes before i...

Embodiment 2

[0026] Example 2 Inhibitory Effect of Compound Danshen Dripping Pills on Rat Mesenteric Mast Cell Degranulation After Ischemia-Reperfusion

[0027] (1) Experimental method

[0028] 1. Test group and control group

[0029] (1) Normal control group: without ischemia-reperfusion treatment.

[0030] (2) Compound Danshen dripping pill administration group: After ischemia-reperfusion, the compound Danshen dripping pill was made into a 50 mg / ml solution with physiological saline, and was continuously dripped (2.6ml / min) on the observed mesentery surface.

[0031] (3) SOD (superoxide dismutase) administration group: at the time of ischemia-reperfusion for 10 minutes, continuously inject SOD through the jugular vein at the dosage of 12000u / kg / hr through the jugular vein until the end of the observation.

[0032] 2. Experimental method: with embodiment one.

[0033] 3. Measuring method: with embodiment one.

[0034] (2) Results

[0035] figure 2 It showed that at 30 minutes of is...

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PUM

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Abstract

The present invention belongs to the field of medicine technology. It relates to an application of compound danshen dripping pills in the preparation o f medicine for inhibiting mast cell degranulation. Said invented research makes the mesenteric mast cell undergo the process of vital staining treatment after ischemic reperfusion and can see that the peroral administration of the compound danshen dripping pills can inhibit the mast cell degranulation due to ischemic reperfusion, so that it can be used in preventing and treating the disease due to mast cell degranulation, specially it can be used as ideal medicine in preventing and treating microcirculation disturbance disease due to mast cell degranulation.

Description

[technical field] [0001] The invention belongs to the field of medicine, and in particular relates to the application of compound danshen dripping pills in the preparation of medicines for inhibiting mast cell degranulation. [Background technique] [0002] Mast cell degranulation is a complex biochemical process and is affected by multiple stimuli. The classic theory is that after the allergen bridges with the IgE molecule on the surface of the mast cell, the IgE molecule is allosteric, which changes the energy metabolism and permeability of the mast cell membrane, and promotes the process of membrane phospholipid methylation and calcium ion channels. open. The influx of calcium ions in the extracellular fluid may lead to the fusion of the granule envelope and the cell membrane through the activity of microfilaments in the brain plasma (cell muscle action), and together with the mutual fusion between the granule envelopes, a complex pathway connecting the extracellular flui...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P9/00A61P43/00
Inventor 韩晶岩秋叶保忠铃木秀和永田博司三浦总一郎织田正也石井裕正
Owner TIANJIN TASLY PHARMA CO LTD