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Preparation of Notoginsen triterpenes injection

A technology of Panax notoginseng saponins and injection, which is applied in the field of preparation of Panax notoginseng saponins injection, can solve problems such as difficult control of technical parameters in production, inconsistent adsorption of active ingredients, and fluctuating product yields. Achieve the effects of environmental protection, easy operation and stable product quality

Inactive Publication Date: 2004-11-17
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, activated carbon will absorb a large amount of water and gas during transportation and storage, which often leads to partial deactivation of activated carbon or poisoning of activated carbon. Therefore, the activity of each batch of activated carbon is different. The amount of active ingredients adsorbed is also inconsistent, which makes it difficult to control the technical parameters in production, and the product yield fluctuates, which brings huge pressure to production management

Method used

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  • Preparation of Notoginsen triterpenes injection
  • Preparation of Notoginsen triterpenes injection
  • Preparation of Notoginsen triterpenes injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]Take 100 g of Panax notoginseng saponins, 9 g of sodium chloride, add 1000 ml of water for injection, stir evenly, heat and boil for 20 minutes, cool the medicinal solution to 50° C., and filter through microporous membranes with pore diameters of 5 μm and 0.2 μm respectively (microporous filter) The membrane is a ceramic membrane material with a molecular weight cut-off of 100,000); the filtrate was refrigerated at 1°C for 5 hours, diluted with water for injection to 3 times the original liquid and boiled, cooled to 15°C, and filtered through one stage respectively ( This filtration is ultrafiltration, membrane material is polysulfone, molecular weight cut-off 80,000), adjusts filtrate content to be 55%, pH value is 6, passes one-stage filtration (this one-stage filtration is that ultrafiltration membrane material is polyacrylonitrile, cut-off Molecular weight 10,000); Fill into 10ml ampoule bottle, seal, sterilize, pack, and obtain the finished product.

Embodiment 2

[0048] Take 100g of Panax notoginseng total saponins, 9g of sodium chloride, add 1000ml of water for injection, stir evenly, heat and boil for 8 minutes, cool the medicinal solution to 50°C, and filter through a 0.45 μm microporous membrane (the microporous membrane is a ceramic membrane material, The membrane molecular weight cut-off is 100,000); the filtrate was refrigerated at 1°C for 6 hours, diluted with water for injection to 3 times of the original medicinal liquid, boiled, cooled to 30°C, and subjected to primary filtration respectively (this secondary filtration is ultra- After filtration, the membrane material is polyamide, and the membrane molecular weight cut-off is 60,000), adjust the filtrate content to be 78%, and the pH value is 6.5, and pass through secondary filtration (this secondary filtration is ultrafiltration, and the membrane material is cellulose diacetate, membrane Molecular weight cut off 9000); Fill into 10ml ampoule bottle, seal, sterilize, pack, ob...

Embodiment 3

[0050] Take 100g of Panax notoginseng saponins, 9g of sodium chloride, add 1000ml of water for injection, stir evenly, heat and boil for 5 minutes, cool the liquid to 55°C, filter through a 0.2 μm microporous membrane (the microporous membrane is a ceramic membrane material, The membrane molecular weight cut-off is 100,000); the filtrate was refrigerated at 4°C for 4 hours, diluted with water for injection to 3 times of the original liquid and boiled, cooled to 20°C, and passed through a stage of filtration respectively (this stage of filtration is ultra- Filter, membrane material is polyamide membrane, molecular weight cut-off 10,000), adjust filtrate content to be 80%, pH value is 6.1, pass secondary filtration (this secondary filtration is ultrafiltration, membrane material is protein membrane, molecular weight cut-off 4000) Fill into 10ml ampoule bottle, seal, sterilize and pack to get the finished product.

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Abstract

The invention discloses a process for preparing Notoginsen triterpenes injection wherein membrane separation method or micro-filtration method are employed in the filtration procedure, based on the soup active ingredient, microorganism and particle diversity, membrane material with interception molecular weight between 1500 to 100000 can be selected to entrap the foreign substance and organism (ineffective composition and pyrogen substances) in the injection by their molecular weight in one or several times.

Description

technical field [0001] The present invention relates to the preparation method of traditional Chinese medicine preparation, more specifically, the present invention relates to the preparation method of Panax notoginseng saponins injection (its drug name is " Xuesaitong injection "). Background technique [0002] "Xuesaitong Injection" is a traditional Chinese medicine preparation made from the active ingredient Panax notoginseng saponins extracted from the traditional precious Chinese medicinal material Panax notoginseng, because the active ingredient Panax notoginseng saponins has significant pharmacological effects on the cardiovascular system, as early as It has been widely used clinically since 1987, and has played a huge role in the treatment of cardiovascular system diseases. Recently, Xuesaitong injection, as a pure natural pharmaceutical preparation, has once again become a focus of attention due to its inherent naturalness, safety and effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/704A61P9/00
Inventor 周志宏
Owner YUNNAN PHYTOPHARML
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