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Preparation of water soluble dragon's blood as medicine

A water-soluble technology of dragon's blood, applied in the field of drug preparation, can solve the problems of wasting drug resources and difficult to achieve curative effect

Inactive Publication Date: 2004-12-08
陈才义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dragon's blood is insoluble in water and is difficult for the human body to absorb. In clinical practice, 90% of dragon's blood is excreted in the stool after oral administration, so it is difficult to achieve the expected curative effect. Therefore, it has not been widely used by people and wasted a lot of precious drug resources

Method used

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  • Preparation of water soluble dragon's blood as medicine
  • Preparation of water soluble dragon's blood as medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: get Cambodia dragon blood bark (Draeaena cam bodiama Pierre ex Gagne Pain), after coarse grinding, soak with alcohol with a concentration of 95%, after recovering the ethanol, prepare Jackie Chan's blood dried ointment for later use; The dried dragon's blood extract block is crushed and then added with ethanol to make the dragon's blood dried extract. Grind and mix ethanol and hydroxypropyl-β-cyclodextrin, the weight percentage of hydroxypropyl-β-cyclodextrin in it is 30%; Grinding, the ratio of the dried dragon's blood clearing paste and the paste is 1:3; the ground dragon's blood clearing paste is prepared into a powdery finished product by spray drying, and the concrete steps are, feed-fog Chemicalization - contact between material mist and air - material mist evaporation - separation of dry products. Compared with the currently available products of Dragon's Blood, this product has a water solubility of 50% at room temperature; After entering the hum...

Embodiment 2

[0010] Embodiment 2: get Cambodia dragon's blood bark (Draeaena cam bodiama Pierre ex Gagne Pain) after crushing, soak with 95% alcohol concentration, after recovering ethanol, prepare Jackie Chan's blood plaster for later use; Base-β-cyclodextrin is ground and mixed, and the weight percentage of hydroxypropyl-β-cyclodextrin in it is 20%. When it is ground into a uniform paste, then add the dragon's blood dried ointment and grind it together. The ratio of the clear paste to the paste is 1:4; the dried dragon's blood clear paste paste ground by the low-temperature freeze-drying method is prepared into a powdery product, and the specific steps are freezing-sublimation-re-drying. . Compared with the currently available dried dragon blood products, this product has a water solubility of 75% at room temperature; After entering the human body, it is quickly decomposed into dragon blood molecules and hydroxypropyl-β-cyclodextrin, dragon blood molecules are absorbed and utilized by t...

Embodiment 3

[0011] Embodiment 3: take Cambodian dragon blood bark (Draeaena cam bodiama Pierre ex Gagne Pain) and pulverize it, soak it in alcohol with a concentration of 95%, recover the ethanol, and prepare Jackie Chan's blood dried ointment for later use; The hydroxypropyl-β-cyclodextrin is ground and mixed, and the weight percentage of hydroxypropyl-β-cyclodextrin is 40%. When it is ground into a uniform paste, then add the dragon's blood dried ointment and grind it together. The ratio of the clear paste to the paste is 1:2; the dried dragon's blood clear paste paste that has been ground by a low-temperature freeze-drying method is prepared into a powdery finished product, and the specific steps are freezing-sublimation-re-drying. . Compared with the currently available products of Dragon's Blood, this product has a water solubility of 50% at room temperature; After entering the human body, it is quickly decomposed into dragon blood molecules and hydroxypropyl-β-cyclodextrin, dragon ...

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Abstract

A process for preparing the water-soluble medicine 'Longxuejie' includes such steps as immersing Draeaena cam bodiama in alcohol, recovering alcohol to obtain its extract, mixing water or alcohol with hydroxypropyl-beta-cyclodextrin, grinding, adding said extract, grinding and spray (or freeze) drying to obtain powder. Its advantages are high medical effect and easy absorption.

Description

technical field [0001] The invention belongs to a preparation method of a medicine, in particular to a method for preparing the dragon's blood into a water-soluble dragon's blood medicine that is easily absorbed by the human body. technical background [0002] Dragon's blood is derived from the agave plant, Draeaena cam bodiama Pierre exGagne Pain. It is used externally for hemostasis and muscle regeneration, and it is used for internal hemostasis and blood circulation. It is a widely used and effective medicine in the folk. However, the dragon's blood is insoluble in water and difficult to be absorbed by the human body. In clinical practice, 90% of the dragon's blood is excreted in the stool when taken orally, which is difficult to achieve the expected curative effect. Therefore, it has not been widely used by people, and a lot of precious drug resources. SUMMARY OF THE INVENTION [0003] The technical problem to be solved by the present invention is to provide a prepara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61P7/04
Inventor 陈才义
Owner 陈才义
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