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Chuanxiong rhizome volatile oil soft capsule and its preparation method

A technology of soft capsules and chuanxiong oil, applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as affecting the efficacy of drugs, and achieve the purpose of increasing arterial blood flow, improving behavioral disorders, and reducing necrotic areas. Effect

Inactive Publication Date: 2005-02-02
长春大政药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the traditional process has caused great damage to phthalides, which will definitely affect the curative effect of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0014] Preparation Example 1: Preparation of Chuanxiong Oil Soft Capsules

[0015] A Chuanxiong oil preparation: 120 kilograms of dried Chuanxiong raw materials are crushed and passed through a No. 2 sieve, placed in a 600L supercritical extraction equipment for extraction, the extraction pressure is 10MPa, the extraction temperature is 40°C, the extraction time is 4 hours, CO 2 The flow rate is 20Kg / Kg Ligusticum chuanxiong·h, the pressure of the first stage separation tank is 8MPa, the temperature is 35°C, the extract is filtered, the filtrate is left to stand, and the oil layer is obtained.

[0016] Preparation of B gelatin solution: 100 g of gelatin, 60 g of glycerin and 100 g of water. Get gelatin and add appropriate amount of water to make it absorb water and swell. In addition, put the glycerin and the remaining water in a glue pot and heat to 70-80°C, mix evenly, add the expanded gelatin, stir, melt, keep warm for 1-2 hours, let stand to make the foam float up, and sc...

preparation example 2

[0019] Preparation Example 2: Preparation of Soft Capsules

[0020] A Chuanxiong oil preparation: 120 kg of dried Chuanxiong raw material is crushed and passed through No. 2 sieve, placed in a 600L supercritical extraction equipment for extraction, the extraction pressure is 8MPa, the extraction temperature is 30°C, the extraction time is 2 hours, CO 2 The flow rate is 10Kg / Kg Ligusticum Chuanxiong·h, the pressure of the first-stage separation tank is 4MPa, the temperature is 20°C, the extract is filtered, the filtrate is left to stand, and the oil layer is taken to obtain the product.

[0021] B Preparation of gelatin solution: 100g of gelatin, 40g of glycerin and 70g of water. Get gelatin and add appropriate amount of water to make it absorb water and swell. In addition, put the glycerin and the remaining water in a glue pot and heat to 70-80°C, mix evenly, add the expanded gelatin, stir, melt, keep warm for 1-2 hours, let stand to make the foam float up, and scrape off the...

preparation example 3

[0025] A Chuanxiong oil preparation: 120 kg of dried Chuanxiong raw material is crushed and passed through the No. 2 sieve, placed in a 600L supercritical extraction equipment for extraction, the extraction pressure is 10MPa, the extraction temperature is 60°C, the extraction time is 12 hours, CO 2 The flow rate is 30Kg / Kg Ligusticum chuanxiong·h, the pressure of the first stage separation tank is 10MPa, the temperature is 40°C, the extract is filtered, the filtrate is left standing, and the oil layer is taken to obtain the product.

[0026] B Preparation of gelatin solution: 100g of gelatin, 60g of glycerin and 140g of water. Get gelatin and add appropriate amount of water to make it absorb water and swell. In addition, put the glycerin and the remaining water in a glue pot and heat to 70-80°C, mix evenly, add the expanded gelatin, stir, melt, keep warm for 1-2 hours, let stand to make the foam float up, and scrape off the floating foam to clean White cloth filter, add 0.007...

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PUM

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Abstract

The present invention provides a Chuanxiong rhizome volatile oil soft capsule and its preparation method and use. The Chuanxiong rhizome volatile oil described in the invention is prepared by a carbon dioxide supercritical extraction method, the contend of the effective component Chuanxiong rhizome phthalide in the Chuanxiong rhizome volatile oil reaches the medicinal standard, and the quality is stable and can be controlled. The invention also provides the use of the Chuanxiong rhizome volatile oil soft capsule for preparing the medicine for curing cerebral apoplexy during recovery period.

Description

technical field [0001] The invention relates to a soft capsule, a preparation method and application thereof, in particular to a Chuanxiong oil soft capsule, a preparation method and application thereof. Background technique [0002] Rhizoma Chuanxiong is recorded in "Pharmacopoeia of the People's Republic of China 2000 Edition" (Part One). Ligusticum chuanxiong is a traditional Chinese medicine, which has the medicinal effects of promoting blood circulation and removing stasis, regulating qi and relieving pain. TCM theory attaches great importance to the normal operation of qi, blood, and body fluid, and believes that stagnation of qi will lead to blood stasis. Cerebral ischemia is due to qi stagnation and blood stasis, and blood vessels are blocked, which leads to nervous system dysfunction. Ligusticum Chuanxiong is a "medicine for qi in the blood". Efficacy, attending stroke into the brain headache, hemiplegia and other diseases. A large number of studies have been co...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P9/10
Inventor 张达磊李桂生曲桂武任召言田京伟
Owner 长春大政药业科技有限公司
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