Microencapsulated saccharomyces and its application

A yeast and microencapsulation technology, applied in microcapsules, fungi, digestive system, etc., can solve the problems of poor stability, high cost, short half-life in vivo, etc., and achieve good biocompatibility and good intestinal adhesion performance. Effect

Inactive Publication Date: 2005-03-09
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in the use of genetically engineered drugs at present, such as: genetically engineered drugs are mostly extracted from the metabolites of genetically engineered bacteria (Escherichia coli or yeast), the separation and purification process for drug preparation is complicated, and the cost is high; The short half-life and other characteristics determine that the current route of administration of genetically engineered drugs is still mostly injection

Method used

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  • Microencapsulated saccharomyces and its application
  • Microencapsulated saccharomyces and its application
  • Microencapsulated saccharomyces and its application

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Example 1: ACA microcapsules containing yeast were prepared under physiological conditions. During the preparation process, the survival rate of yeast was 100%, and the yeast content was 10%. 8 One / ml microcapsules, the particle size of the microcapsules is precisely controllable in the range of 100-1000μm.

example 2

[0018] Example 2: After oral perfusion of ACA microcapsules containing indicator dyes in mice, the mice were killed 2 hours later and the stomach wall was dissected, and the complete microcapsules were seen. (See image 3 ).

example 3

[0019] Example 3: ACA microcapsules containing bovine hemoglobin showed zero-order release in simulated gastric fluid hemoglobin, and first-order release curve in simulated intestinal fluid.

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Abstract

A yeast in the form of micro capsule for controlling the release of protein medicine to treat uremia, hepatal failure, phenylketonuria, cancer, etc has the sodium alginate-chitosan-sodium alginate structure, and the yeast is dispersed proportionally in the liquid contained in the micro capsule.

Description

technical field [0001] The invention relates to a microencapsulated yeast that can grow, metabolize and secrete genetically engineered medicine in the intestinal tract. [0002] The present invention also relates to the application of the above-mentioned microencapsulated yeast in treating diseases. Background technique [0003] With the development of molecular biology technology, the large-scale production of protein and polypeptide genetic engineering drugs has become a reality, and it has been widely used in clinical practice [Document 1: Pennisi E. Breakthrough of the year. Genomics comes of age. Science, 2000, 290( 5500): 2220-21], [Document 2: Peltonen L, McKusick VA. McKusick. Genomics and medicine. Dissecting human disease in the postgenomic era. Science, 2001, 291(5507): 1224-1229]. However, there are still some problems in the use of genetically engineered drugs at present, such as: genetically engineered drugs are mostly extracted from the metabolites of genetic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61P1/16A61P5/00A61P13/00A61P25/00A61P35/00A61P43/00C12N1/16
Inventor 马小军于炜婷薛伟明
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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