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Method for producing L-ornithine hydrochloride

A technology of ornithine hydrochloride and arginine hydrochloride, which is applied in the field of preparation of L-ornithine hydrochloride, can solve the problems of unseen production patents and related reports, amino acid racemization, etc., and achieve The effect of shortening the production cycle, reducing the amount of resin, and improving the yield of finished products

Inactive Publication Date: 2005-03-16
WUHAN GRAND HOYO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The method of chemical hydrolysis of L-arginine hydrochloride, although the reagents are easy to get, it is easy to cause amino acid racemization
This problem has not been well resolved, but was shelved
Since then, there have been no production patents and related reports on the production of L-ornithine hydrochloride by alkaline hydrolysis of L-arginine hydrochloride

Method used

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  • Method for producing L-ornithine hydrochloride

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Embodiment Construction

[0010] Because amino acids are more likely to undergo racemization reactions in alkaline media, we control the reaction conditions so that the resulting products do not undergo racemization; the properties of amino acids are very close, and it is difficult to separate and purify by general methods. We use ion exchange resins Chromatography solves the recovery and purification of L-ornithine hydrochloride in the mother liquor. For this reason, we screen the optimum temperature, the most appropriate weak base substance and arginine hydrochloride and OH - Concentration, including appropriate hydrolysis reaction time, so that racemization does not occur:

[0011] At 100~110℃, 0.4~0.5M weak lye Ba(OH) 2 Hydrolyze L-arginine hydrochloride in medium for 2-3 hours, neutralize with dilute sulfuric acid to remove Ba 2+ , Concentrated and crystallized to obtain L-ornithine hydrochloride crystal crude product, the crude product was recrystallized in pure water to obtain pure product, an...

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PUM

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Abstract

The invention discloses a method for producing L-ornithine hydrochloride through weak Ba(OH)2 hydrolysis L-arginine hydrochloric salts, neutralizing with dilute sulfuric acid, removing Ba2+, obtaining L-ornithine hydrochloride crystallized crude product through concentrated crystallization, re-crystallizing in pure water to obtain the pure product.

Description

technical field [0001] The invention belongs to the preparation method of amino acid, in particular to the preparation method of L-ornithine hydrochloride. Background technique [0002] Developing amino acid production to meet the growing needs of my country's medical care industry is a long-term goal pursued by some governments and competent departments in our country. The production process of amino acids includes many ways such as synthesis, microbial fermentation, natural protein extraction, and enzymatic synthesis. Microbial fermentation and enzymatic synthesis are popular methods in foreign countries. The development cycle of this type of process is long and the capital investment is large. Along this route, my country is at a relatively disadvantaged position. For this reason, we need to vigorously develop the production process and products suitable for our country's national conditions, to gain a firm foothold in the international market on the basis of several lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/16C07C229/26
Inventor 刘爱福
Owner WUHAN GRAND HOYO
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