Method for chemical synthesis of N-[1 (1)-carbethoxy-3-hydro cinnamyl]-L-ulamine -N- carboxylic anhydride

A technology of ethoxycarbonyl and chemical synthesis, applied in the direction of organic chemistry and the like, can solve the problems of long reaction time of the synthesis method, increase the production cost, potential safety hazards, etc., and achieve the effects of eliminating potential production safety hazards, reducing the production of three wastes, and reducing the amount of consumption.
CN1611494AActive Publication Date: 2005-05-04ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2005-05-04

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Abstract

The invention relates to a kind of chemosynthesis method of N-[1(S)-ethoxy carbonyl-3-phenyl propyl]-L-alanine-N-hydroxy acid anhydride, which is the medicine midbody for synthesizing Pulitzer series medicine such as Enalapril, Ramipril, Lisinopril and so on. The invention uses couple (trichloromethyl) ester carbonate and N-[1(S)-ethoxy carbonyl-3-phenyl propyl]-L-alanine as row material, and get the product by reacting with catalyst action in organic solvent. This chemosynthesis method is a manufacturing method of N-[1(S)-ethoxy carbonyl-3-phenyl propyl]-L-alanine-N-hydroxy acid anhydride, which has acquirable raw material, low production cost, and no three wastes normally.
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Description

(1) Technical field

[0001] The present invention relates to a kind of chemical synthesis method of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine-N-carboxylic acid anhydride, especially using N-[1(S)- Ethoxycarbonyl-3-phenylpropyl]-L-alanine [N-(1(S)-ethyloxycarbonyl-3-phenylpropyl)-L-ananine] and bis(trichloromethyl) carbonate [bis(trichloro Methyl)carbonate] is a chemical synthesis method for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine-N-carboxylic acid anhydride by reacting raw materials in an organic solvent under the action of a catalyst. N-[1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine-N-carboxylic acid anhydride is mainly used in the synthesis of enalapril, ramipril, lisinopril, etc. series of drugs. (2) Technical background

[0002] Before the present invention was made, the existing method of chemically synthesizing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine-N-carboxylic acid anhydride was made by N-[1(S) -Ethoxycarbonyl-3-phenylpropyl]-L-a...

Claims

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