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Active extract of lamtophlomis rotata and its preparing method and use

A unique flavor and extract technology, applied in the field of medicine, can solve the problem of large dosage

Active Publication Date: 2005-05-18
GUANGZHOU BAIYUNSHAN CHENLIJI PHARMA FAB CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application No. 0213469.9 discloses a unique dispersible tablet, but these three preparations are all made from the unique water extract, which has the disadvantage of taking a large amount of food. Generally, it needs to take 3 capsules orally once, Capsules 300mg, three times a day, equivalent to 9g crude drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1, water extraction and alcohol precipitation method: take the coarse powder of the whole herb and root (1:1) of Duyiwei, mix evenly, add water to decoct 2 times, combine each decoction, concentrate, add ethanol to adjust alcohol Concentration to 60%, stand still. After the precipitation is complete, pour out the supernatant, filter, concentrate the medicinal solution to a concentration of 1:2 equivalent to the amount of the medicinal material, and set aside;

Embodiment 2

[0059] Embodiment 2. Alcohol extraction and water precipitation method: Weigh the coarse powder of the whole herb and root (1:1) of Duyiwei, mix evenly, add 60% ethanol for reflux extraction 3 times, combine the alcohol extracts, recover ethanol, and medicinal solution Concentrate to a relative density of 1.0-1.2, add an appropriate amount of water to mix and stir evenly, and let stand. After the precipitation is complete, pour out the supernatant, filter, concentrate the medicinal solution to a concentration of 1:2 equivalent to the amount of the medicinal material, and set aside;

Embodiment 3

[0060] Embodiment 3, alcohol percolation extraction method: take the coarse powder of the whole herb and root (1:1) of Duyiwei, mix evenly, add 70% ethanol after soaking, carry out percolation with the speed of 5ml / min, collect percolation Wet the liquid, recover ethanol, concentrate the medicinal liquid to a relative density of 1.2, add an appropriate amount of water to mix and stir evenly, and let stand. After the precipitation is complete, pour out the supernatant, filter, concentrate the medicinal solution to a concentration of 1:2 equivalent to the amount of the medicinal material, and set aside;

[0061] The medicinal liquids of Examples 1, 2, 3, and three extraction methods were separated and eluted by the same method through the macroporous resin, concentrated into an extract after recovering ethanol, and spray-dried to obtain a dry powder. The measurement results are shown in the table below;

[0062] Process method

[0063] 2. Further separation and purific...

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PUM

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Abstract

The medicine plant material Lamiophlomis rotata or its root is alcohol or water extracted to obtain the extract liquid, and the extract liquid is further separated and purified to obtain active extract, which contains total flavone in 50-80 wt% counted in rutin and luteolin in 1.0-5.0 wt%. The present invention has raised curative effect and reduced taken amount, and is used in treating various kinds of pain, hemorrhage, etc. The active extract may be added with pharmaceutically acceptable supplementary material to prepare various orally taken preparation, preferably dripping pill.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an active extract containing total flavonoids extracted from a single plant unique as a raw material. The invention also relates to the preparation method and application of the active extract. Background technique [0002] Duyiwei Tablets and Duyiwei Capsules are traditional Chinese patent medicines, which are processed from the whole herb or root of a single plant, Duyiwei, and recorded in the Chinese Pharmacopoeia. Incisional pain after various surgical procedures. Bleeding, surgical fractures, sprains, rheumatic arthralgia, metrorrhagia, dysmenorrhea, gingival swelling, bleeding, etc. Chinese patent application No. 0213469.9 discloses a unique dispersible tablet, but these three preparations are all made from the unique water extract, which has the disadvantage of large dosage, and generally needs to take 3 capsules orally once each time. Capsule 300mg, three times a da...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P1/02A61P7/04A61P15/00A61P19/08A61P29/00
Inventor 许招懂陈路林钟华林陈文俊郭钟慧宁德山彭德光吴德玄
Owner GUANGZHOU BAIYUNSHAN CHENLIJI PHARMA FAB CO LTD
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