Dripping pills of clove leaf and its preparation process
A technology of cloves and dripping pills is applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of excellent onset speed, rapid dispersion and reduced dosage.
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Embodiment 1
[0009] prescription:
[0010] Clove leaves 140g
[0011] Macrogol 4000 30g
[0012] A total of 1000 pills were made, each weighing 50 mg.
[0013] Preparation method: Take 140g of clove leaves, add water (12 times the amount for the first time, 8 times the amount for the second time) and decoct twice, the first time is 2 hours, and the second time is 1 hour. The extracts were combined and filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.10-1.12 (60°C thermal measurement), spray-dried to obtain a dried medicinal powder, which was added to polyethylene glycol 4000 melted at 85°C, and stirred evenly. The selected dripper with the inner and outer diameter of the drop opening is 3.2 / 5.8 (mm / mm), and the drop distance is 5cm. Drop into methyl silicone oil at 15-20°C at a rate of 30d / min and shrink into pellets, sieve and wipe dry to obtain.
Embodiment 2
[0015] prescription:
[0016] Clove leaves 140g
[0017] Macrogol 6000 30g
[0018] A total of 1000 pills were made, each weighing 50 mg.
[0019] Preparation method: Take 140g clove leaves, add water (12 times the amount for the first time, 8 times the amount for the second time) and decoct twice, the first time is 2 hours, and the second time is 1 hour. The extracts were combined and filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.10-1.12 (60°C thermal measurement), spray-dried to obtain a dried medicinal powder, which was added to polyethylene glycol 6000 melted at 90°C, and stirred evenly. The selected dripper with the inner and outer diameter of the drop opening is 3.2 / 5.8 (mm / mm), and the drop distance is 4cm. Drop into methyl silicone oil at 15-20°C at a rate of 30d / min to shrink into pellets, sieve, and dry to obtain.
Embodiment 3
[0021] prescription:
[0022] Clove leaves 140g
[0023] Macrogol 4000 15g
[0024] Macrogol 6000 15g
[0025] A total of 1000 pills were made, each weighing 50 mg.
[0026] Preparation method: Take 140g clove leaves, add water (12 times the amount for the first time, 8 times the amount for the second time) and decoct twice, the first time is 2 hours, and the second time is 1 hour. The combined extracts were filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.10 to 1.12 (60°C thermal measurement), spray-dried to obtain a dried medicinal powder, which was added to polyethylene glycol 4000 and 6000 (1: 1) in the mixture, stir well. The selected dripper with the inner and outer diameter of the drop opening is 3.2 / 5.8 (mm / mm), the drop distance is 4cm, dripped into the methyl silicone oil at 15-20°C at a drop rate of 30d / min, and shrinks into pellets, screened, and wiped dry , that is.
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