High-purity scutellarin injection agent

A technology of scutellarin and scutellarin, applied in the field of medicine, can solve the problems of high impurity content, large irritation, and many adverse reactions, and achieve the effect of high purity, low irritation, and few adverse reactions

Inactive Publication Date: 2005-07-20
GUANGDONG QIFANG MEDICINES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The deficiency of the prior art is that the content of scutellarin in the scutellarin used in all preparations is only about 60%-70% (HPLC method), and the impurity content is high, causing great irritation and many adverse reactions. set up obstacles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Take scutellarin, add an appropriate amount of water for injection, adjust the pH to 5-8, stir to dissolve, and make scutellarin injection containing 5-200mg per vial according to the preparation method of small-volume injection.

example 2

[0025] Take scutellarin, add an appropriate amount of water for injection, adjust the pH to 5-8, stir to dissolve, add an isotonic regulator (sodium chloride or glucose or fructose or xylitol or maltose or a mixture thereof), and press the volume The preparation method of the volume infusion is made into a large volume injection of scutellarin containing 5-200 mg in each bottle.

example 3

[0027] Take scutellarin, add an appropriate amount of water for injection, adjust the pH to 5-8, stir to dissolve, add freeze-dried auxiliary materials, pack in freeze-dried bottles at constant volume, and make each bottle containing 5- 200mg of scutellarin freeze-dried powder for injection, or aseptic powder prepared by spray drying or freeze-drying, and further divided into finished products.

[0028] It can also be operated without lyophilized auxiliary materials.

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PUM

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Abstract

The present invention relates to a high-purity breviscapine injection. Said injection contains breviscapine whose purity is 90.0%-99.5% (containing end point) and physiologically-acceptable salt.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a high-purity scutellarin injection. Background technique [0002] Breviscapine is a class of flavonoids isolated from Breviscapus breviscapus on the basis of folk medicine, mainly containing scutellarin (as 5,6,7,4'-tetrahydroxyflavone-7-O-glucuronic acid Glycosides), breviscapine and other flavonoids. Since the 1970s, Yunnan Provincial Institute of Materia Medica, Yunnan Biopharmaceutical Factory and many other units have used its total flavonoids as raw materials to make various preparations, such as breviscapine injection, breviscapine injection, and breviscapine tablets , breviscapine for injection, etc. Modern pharmacological research shows that breviscapine has the following effects: [0003] 1. Increase cerebral blood flow, reduce vascular resistance, and improve blood-brain barrier permeability. [0004] 2. Fight against platelet aggregation and hyperviscosity caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P7/02A61P9/10A61P9/12
Inventor 张登科刘军刘云涛
Owner GUANGDONG QIFANG MEDICINES CO LTD
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