Palatable oral suspension and method

Abstract

A drug formulation in the form of a dry powder is provided which when mixed with water forms a palatable oral suspension substantially free of bitter taste, the dry powder being formed of a drug, preferably des-quinolone, which in solution has a bitter taste, and a pH modifying agent which is preferably an alkaline material such as L-arginine, where upon mixing the dry-powder in water causes the drug to have reduced solubility or precipitate in-situ to form a palatable oral suspension essentially free of bitter taste. An oral suspension, methods for making same and a method for masking the bitter taste of drugs employing one or more pH modifying agents are also provided.

Description

[0001] This application claims priority to US Provisional Application 60 / 363,704, filed March 12, 2002, which is hereby incorporated by reference in its entirety.

[0002] The present application relates to a palatable oral suspension drug formulation comprising suspended particles of a readily water-soluble drug such as des-quinolone (des-quinolone) antibacterial agent, wherein the normal bitter taste of the drug is masked, and also relates to a combination of the above drug and pH A dry powder consisting of a regulator which, when mixed with water, produces an in-situ reduction in solubility or precipitation to form a suspension of the above-mentioned powder which is substantially free of bitterness, also relates to a process for the preparation of the above-mentioned oral suspension, and also It relates to a method for masking the bitter taste of orally administered soluble bitter drugs without insoluble polymer or paraffin coating or microencapsulation process. Background o...

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