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Taste masked compositions of erythromycin A and derivatives thereof

A technology of erythromycin derivatives and compositions is applied in the field of pharmaceutical compositions containing erythromycin A or its derivatives and alginic acid, and can solve problems such as cost, leakage of solvent vapor into the environment, and employee safety.

Inactive Publication Date: 2005-08-10
RANBAXY LAB LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technique also has its disadvantages - it is technique intensive and the coated granules are easily broken by chewing and squeezing
Adopting this method on an industrial scale raises many concerns, including employee safety, leakage of solvent vapors into the environment, and expense

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] We have now found that when erythromycin A or a derivative thereof, such as clarithromycin, is mixed with alginic acid, a composition with improved taste is obtained because the alginic acid effectively masks the bitter taste of the active ingredient. The solid formulation of erythromycin A or its derivatives mixed with alginic acid is characterized in that it significantly reduces the bitterness of the active ingredient compared to some existing formulations. According to one embodiment, erythromycin A or a derivative thereof and alginic acid are prepared and administered in a drug to polymer ratio of from about 2.5:1 to about 50:1. More specifically, the ratio is 10:1 to 30:1. Alginic acid can be added as alginic acid or any salt thereof, including sodium alginate, calcium alginate, and the like.

[0028] Generally, the method for manufacturing taste-masking granules of erythromycin A or its derivatives comprises mixing erythromycin A or its derivatives, alginic acid...

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PUM

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Abstract

A pharmaceutical composition includes erythromycin A or a derivative thereof and alginic acid. The alginic acid provides taste masking of the erythromycin A or derivative. The erythromycin A derivative may be clarithromycin and the alginic acid may be one or both of alginic acid and its salt. The salt may be one or more of sodium alginate and calcium alginate. The pharmaceutical composition may further include one or more of a binder, a disintegrant, a flavoring agent, and a coating. The pharmaceutical composition also may include one or more active ingredients, including omeprazole, metronidazole, amoxicillin, rifampicin, lansoprazole, ciprofloxacin, ethambutol, and ritonavir. The erythromycin A or a derivative thereof and the one or more active ingredients may be combined in a single pharmaceutical composition.

Description

[0001] technical field of invention [0002] The field of the invention relates generally to taste masking of erythromycin A and derivatives with alginic acid. Background of the invention [0003] Erythromycin and its derivatives are very bitter drugs, and even trace amounts dissolved in liquid dosage forms are often perceived as having an unpleasant taste. However, they are also the drug of choice for treating common middle ear and upper respiratory tract infections in children and some pneumonias that afflict middle-aged and older adults. Administering this drug to children and the elderly presents a challenge due to difficulties swallowing solid oral dosage forms. For these patients, medications are often formulated in liquid form such as solutions, emulsions, and suspensions, which often obviously exposes the active pharmaceutical ingredient to the taste buds. [0004] Taste masking of this drug is required to ensure patient compliance during treatment. Conventional tas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/50A61K31/43A61K31/4439A61K31/7048A61K31/734A61K38/55
CPCA61K9/5078A61K9/1652A61K31/734A61K31/7048A61K9/1676A61K31/43A61K31/4439A61K2300/00A61K9/16
Inventor R·达布里V·纳加普拉萨德R·马利克
Owner RANBAXY LAB LTD
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