Novel diazabicyclic biaryl derivatives

A technology for diazabicyclic and derivatives, which is applied in the field of diazabicyclic biaryl derivatives, and can solve problems such as not being disclosed
CN1653068AInactive Publication Date: 2005-08-10NEUROSEARCH AS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NEUROSEARCH AS
Publication Date
2005-08-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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Description

technical field

[0001] The present invention relates to novel diazabicyclic biaryl derivatives which have been found to be cholinergic ligands of nicotinic acetylcholine receptors and modulators of monoamine receptors and transporters.

[0002] Due to their pharmacological profile, the compounds of the present invention can be used to treat numerous diseases or conditions related to the cholinergic system of the central nervous system (CNS), peripheral nervous system (PNS), diseases or conditions related to smooth muscle contraction , endocrine diseases or conditions, diseases or conditions associated with neurodegeneration, diseases or conditions associated with inflammation, pain, and withdrawal syndromes induced by cessation of chemical substances. Background of the invention

[0003] The endogenous cholinergic neurotransmitter acetylcholine exerts its biological effects through two types of cholinergic receptors, muscarinic acetylcholine receptors (mAChR) and nicotinic a...

Claims

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