Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine

Abstract

Disclosed is a process for producing a solution of a daughter radionuclide that is substantially free of impurities by contacting an aqueous parent-daughter radionuclide solution with a first separation medium, eg. Chromatographic column. The product solution of the desired daughter radionuclide is then contacted with a second separation medium to produce a pure daughter radionuclide solution.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from the following provisional applications: No. 60 / 372327, filed April 12, 2002; No. 10 / 159003, filed May 31, 2002; No. 10 / 261031 and No. 10 / 351717, filed January 27, 2003. Background technique [0003] The use of radioactive materials has become readily accepted in diagnostic medicine because these procedures are safe, minimally invasive, affordable, and can provide clinicians with unique structural and / or functional information not available by other methods. The availability of nuclear medicine is demonstrated by the 13 million diagnostic procedures performed each year in the United States alone, corresponding to 1 in 4 hospital visits treated with nuclear medicine. [See, Adelstein et al. Eds., Isotopes for Medicine and the Life Science; National Academy Press, Washington, DC (1999); Wagner et al., "Expert Panel: Forecast Future Demand for Medical Isotopes," Department of Energy,...

AI Technical Summary

Problems solved by technology

[0038] The deleterious effect of radiation degradation described above is a major difficulty in the development of new therapeutic radionuclide generators

Any damage to the carrier material of conventional generators jeopardizes separation efficiency, may cause penetration of the parent radionuclide and could result in fatal radiation doses if administered to a patient

Such catastrophic events could theoretically be prevented by integrating high quality controls into nuclear medicine operations, but any lack of safe predictable generator behavior is the responsibility of nuclear medicine, the hospital, and their respective collaborators

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