Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine

A radionuclide and affinity technology, applied in the field of multi-column reverse selective generators for the preparation of ultra-pure radionuclide, can solve the problem of lack of safe predictability, endangering separation efficiency, parent radionuclide crossover To achieve the effect of maintaining chemical integrity, reducing the possibility of contamination, and good chromatographic performance

Inactive Publication Date: 2005-08-24
PG RES FOUND
View PDF32 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] The deleterious effect of radiation degradation described above is a major difficulty in the development of new therapeutic radionuclide generators
Any damage to the carrier material of conventional generators jeopardizes separation efficiency, may cause penetration of the parent radionuclide and could result in fatal radiation doses if administered to a patient
Such catastrophic events could theoretically be prevented by integrating high quality controls into nuclear medicine operations, but any lack of safe predictable generator behavior is the responsibility of nuclear medicine, the hospital, and their respective collaborators

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
  • Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
  • Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0148] All acids were trace metal grade and all other chemicals were ACS reagent grade and used as received. 207 Bi and 133 Ba radiotracers were evaporated to dryness twice in concentrated nitric acid and dissolved in 0.50M HNO before use. 3 middle. Standard radiometric procedures were used throughout, and all count rates were background corrected.

[0149] Extraction chromatography material was prepared using the general procedure described previously. [See Horwitz et. al., Anal. Chem., 63:522-525 (1991). ] Briefly, 0.25 M tris-n-octylphosphine oxide (TOPO) in n-dodecane (0.78 g) was dissolved in about 25 mL of ethanol and mixed with 50-100 μm of Amberchrom ￡ - CG71 resin (3.30 g) was mixed in about 25 mL of ethanol. The mixture was rotated on a rotary evaporator at room temperature for about 30 minutes, after which time the ethanol was distilled under vacuum. The resulting solid is called TOPO resin, which corresponds to Amberchrom ￡ - CG71 loaded with 0.25M TOPO / n-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Disclosed is a process for producing a solution of a daughter radionuclide that is substantially free of impurities by contacting an aqueous parent-daughter radionuclide solution with a first separation medium, eg. Chromatographic column. The product solution of the desired daughter radionuclide is then contacted with a second separation medium to produce a pure daughter radionuclide solution.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from the following provisional applications: No. 60 / 372327, filed April 12, 2002; No. 10 / 159003, filed May 31, 2002; No. 10 / 261031 and No. 10 / 351717, filed January 27, 2003. Background technique [0003] The use of radioactive materials has become readily accepted in diagnostic medicine because these procedures are safe, minimally invasive, affordable, and can provide clinicians with unique structural and / or functional information not available by other methods. The availability of nuclear medicine is demonstrated by the 13 million diagnostic procedures performed each year in the United States alone, corresponding to 1 in 4 hospital visits treated with nuclear medicine. [See, Adelstein et al. Eds., Isotopes for Medicine and the Life Science; National Academy Press, Washington, DC (1999); Wagner et al., "Expert Panel: Forecast Future Demand for Medical Isotopes," Department of Energy,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G21G4/08
CPCG21G1/0005G21G4/08
Inventor P·E·霍尔维茨A·H·邦德
Owner PG RES FOUND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap