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Catalyst asymmetric catalytic hydrogenation, preparation method and application

A catalyst, asymmetric technology, used in catalyst activation/preparation, physical/chemical process catalysts, chemical instruments and methods, etc., can solve the problems of cumbersome splitting, toxic side effects, waste of human, material and financial resources, etc., to achieve high optical Selective, highly active and effective

Inactive Publication Date: 2005-08-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If sold in the form of racemate without chiral resolution, drugs with different optical configurations have different physiological and pharmacological activities, which may cause certain toxic and side effects in the human body; When selling, it needs to go through cumbersome splitting, resulting in a great waste of manpower, material and financial resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Add about 20ml of distilled water to 1.406g of alumina, then dropwise add 4ml of chloroplatinic acid aqueous solution (concentration is 18.5mg Pt / ml) under electromagnetic stirring, the loading capacity of metal platinum is 5.0% (weight percentage) After impregnating for 4-6h under continuous stirring, the excess water was evaporated to dryness in a rotary evaporator, and then the catalyst precursor was dried overnight (about 16h) in an oven at 120°C. (2) Calcining the catalyst precursor obtained in step 1 at 200° C. for 2 hours in a muffle furnace. (3) Put the catalyst precursor obtained in step 2 in sodium formate solution (the consumption of sodium formate is about 10 times of the molar amount of platinum contained in the catalyst, the temperature is 90°C, after reflux for 1h, the catalyst is filtered, and the catalyst is filtered with a large amount of hot distilled water washing, drying at 120°C for 24h) and reduction to obtain the catalyst. The number of the ...

Embodiment 2

[0024] Same as Example 1, except that the calcination temperature in step 2 is 350°C. The prepared catalyst number is M2-350. The dispersion degree of metallic platinum on the alumina surface and the average size of platinum particles measured by CO chemisorption are shown in Table 1.

Embodiment 3

[0026] Same as Example 1, except that the calcination temperature in step 2 is 500°C. The prepared catalyst number is M2-500. The dispersion degree of metallic platinum on the alumina surface and the average size of platinum particles measured by CO chemisorption are shown in Table 1.

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Abstract

A catalyst for asymmetrical catalytic hydrogenation, such as the one of ethyl pyruvate to generate (R)-(+)-ethyl lactate, has a molecular formula: Pt / Al2O3. It is prepared from chloroplatinic acid and aluminium oxide through dipping, drying, calcining at different temps in muffle furnace, and reducing in the aqueous solution of sodium formate. Its advantages are high conversion rate, and high optical selectivity to product.

Description

technical field [0001] The invention relates to a catalyst for asymmetric catalytic hydrogenation reaction. [0002] The present invention also relates to a method for preparing the above-mentioned catalyst. [0003] The present invention also relates to the application of the above-mentioned catalyst in the catalytic reaction of α-keto ester. Background technique [0004] In the past ten years, people's demand for single-enantiomer chiral compounds is huge and increasing year by year. This demand is mainly reflected in the fields of medicine, pesticides and fine chemicals. Taking the pharmaceutical market as an example, in 2002, the global sales volume of single enantiomer drugs exceeded 159 billion US dollars (an increase of 8% compared with 2001). Asymmetric catalysis plays an important role in all methods to obtain single enantiomer compounds, and this method has been widely used in many types of asymmetric synthesis reactions. Asymmetric catalytic reaction systems in...

Claims

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Application Information

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IPC IPC(8): B01J23/42B01J37/16
Inventor 李灿李晓红韩涤非应品良
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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