Compounds useful in the manufacture of an anti-inflammatory androstane derivative

A compound and product technology, applied in the field of treatment of inflammatory diseases and allergic diseases, can solve the problems of difficult understanding of pharmacodynamics and pharmacokinetics
CN1680423AInactive Publication Date: 2005-10-12GLAXO GRP LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GLAXO GRP LTD
Publication Date
2005-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

According to one aspect of the invention, there is provided a preparation method of an intermediate compound of formula (II) of the compound of the formula (I). There are also provided novel intermediate compositions.
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Description

[0001] This application is an invention with the filing date of August 3, 2001 and the name is "6α, 9α-difluoro-17α-[(2-furyl carboxyl)oxy]-11β-hydroxyl-16α- as an anti-inflammatory agent Methyl-3-oxo-androst-1,4-diene-17-thiocarboxylate S-fluoromethyl ester" Chinese patent application (national application number is No.01816662.8, international application number is PCT / GB01 / 03495) divisional application. technical field

[0002] The invention relates to a novel anti-inflammatory and anti-allergic androstane series compound and a preparation method thereof. The invention also relates to pharmaceutical formulations containing said compounds and their use in therapy, especially in the treatment of inflammatory and allergic diseases. Background technique

[0003] Glucocorticoids having anti-inflammatory properties are well known and widely used in the treatment of inflammatory diseases or conditions such as asthma and rhinitis. For example, US Patent 4335121 discloses 6α,9α...

Claims

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