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Catheter with tissue protective mantle, preparation method and application

A mantle and protective technology, applied in surgery, medical science, ophthalmic surgery, etc., to achieve the effect of increasing mechanical strength and biological properties, avoiding tear damage, and preventing adhesion

Active Publication Date: 2021-04-06
GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings and deficiencies of the existing artificial lacrimal ducts, the primary purpose of the present invention is to provide a catheter with a tissue-protective mantle. The membrane is double-layered, which are the outer anti-adhesion layer and the inner lubricating layer, both of which are composed of biomedical polymers. When implanted, it can not only prevent adhesion, but also the mantle can be easily separated from the tube core to avoid contact with the tissue. protection against adhesion damage

Method used

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  • Catheter with tissue protective mantle, preparation method and application
  • Catheter with tissue protective mantle, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The silicone rubber catheter with a diameter of 0.6mm is fully dried as the main tube core, preheated with hot air and immersed in PEG (molecular weight 2k) 80 o After 5 seconds, the C melt was slowly taken out, cooled naturally, and the thickness of the obtained inner layer was 0.2mm. Then it was fully immersed in 0.1% chitosan (150k) acetic acid solution for 1 second, and then vertically removed to dry, and the outer layer with a thickness of 0.01mm was obtained. , the material is shaped by 0.01M sodium hydroxide solution, rinsed twice in pure water, and dried to obtain the product.

Embodiment 2

[0040] After the TPU catheter with a diameter of 0.6mm is fully dried, it is used as the main tube core, immersed in 10% PVP (molecular weight 40k) alcohol solution for 10s, then cooled naturally, repeated twice, and the thickness of the inner layer obtained is 0.22mm, and then fully immersed Put it in 3% sodium alginate (80k) solution for 5 seconds and then quickly dry it to obtain an outer layer with a thickness of 0.15mm. The material is shaped by 0.05M calcium chloride solution, rinsed twice in pure water, and dried to obtain the product .

Embodiment 3

[0042] A TPE catheter with a diameter of 0.8mm is fully dried as the main tube core, immersed in a 0.5% PEG (molecular weight 20k) methylene chloride solution for 2 seconds, then taken out, vacuum-dried to obtain an inner layer with a thickness of 0.1mm, and then fully immersed in 0.5% Put it in the hyaluronic acid (1000k) solution for 1 second and then lift it up vertically to dry to obtain an outer layer with a thickness of 0.08mm. The material is subjected to a 0.05M BDDE solution for 5 minutes, washed and dried, repeated twice, and rinsed twice in pure water. , to obtain the product after drying.

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Abstract

The invention discloses a catheter with a tissue protective mantle, a preparation method and an application thereof. The material is composed of a catheter tube core and a mantle covering the outside of the tube. The mantle includes an outer anti-adhesion layer and an inner lubricating layer , the outer and inner layers of the mantle are made of biomedical materials. In the present invention, the anti-adhesion layer of the mantle outer layer is made of water-soluble biomedical materials, and the outer layer can play the role of anti-adhesion when implanted in the body, and the inner layer material can be used as a plasticizer and lubricate after being dissolved by tissue fluid. The tearing injury caused by adhesion is reduced when taking the tube, and it is suitable for use as a component material of lacrimal duct intubation, and improves the anti-adhesion performance of existing materials.

Description

technical field [0001] The invention relates to the field of biomedical devices, in particular to a catheter with a tissue-protective mantle, a preparation method and application thereof, which can be implanted as a medical device component for drainage for lacrimal duct reconstruction surgery. Background technique [0002] Chronic dacryocystitis, canaliculus stenosis, nasolacrimal duct stenosis, puncta stenosis, obstruction, and canaliculus rupture are common and frequently-occurring diseases in ophthalmology, accounting for about 3% of the cases treated in ophthalmology. The reason is inflammation , trauma, tumor, congenital anomaly, and parasites, etc., the clinical symptoms are epiphora or profuse tearing, and pus. In acute attacks, the skin at the lower part of the inner corner of the eye is red, swollen, and painful. In severe cases, it can lead to blindness and even invade the intracranial It is life-threatening and has a great impact on the life and work of patients....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/007A61L31/04A61L31/06
CPCA61F9/00772A61L31/042A61L31/048A61L31/06C08L71/02C08L39/06C08L5/08C08L5/04
Inventor 别拓铭易静楠张爱华官习鹏
Owner GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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