Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Biologic synthesis of perylene quinone compound

A biosynthesis and compound technology, applied in the field of biocatalytic synthesis of compounds, can solve the problems of cumbersome artificial synthesis steps and low total amount of perylenequinone compounds

Inactive Publication Date: 2005-10-12
YUNNAN UNIV
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the artificial synthesis steps are cumbersome, and the synthesis of perylenequinone skeleton compounds through more than a dozen steps of reactions is only of theoretical research significance, and a large amount of perylenequinone compounds can only be obtained through biosynthesis
Although there are some documents so far that have initially explored the biosynthesis of perylenequinone compounds, such as "Biocatalytic synthesis of perylenequinone compounds" ("Molecular Catalysis", 2000, 14 (14), 300-302); Biosynthesis" ("Journal of Tropical Crops", 1998, 19 (Supplement), 45); "Study on solid-state fermentation process of perylene quinones producing bacteria" ("Journal of Yunnan University", Natural Science Edition, 2000, 22(5), 389 -391) and other articles, but the total amount of perylenequinone compounds in the product is very low, which is far from practical application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biologic synthesis of perylene quinone compound
  • Biologic synthesis of perylene quinone compound
  • Biologic synthesis of perylene quinone compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0063] See the examples below.

[0064] The fungus Ascomycetes Hypomyces(Fr)Tul.sp, which grows in the mountainous area of ​​western Yunnan, is identified as Ascomycetes, Hypomycetes, and mycoparasites after collection. The slant medium was potato juice dextrose agar medium. The seed medium was 20 grams of glucose, 1 gram of KH per liter of potato juice 2 PO 4 , 0.5 g MgSO 4 .7H 2 O, 0.1 g CaCl 2 .2H 2 O, 10 mg Vitamin B 1 , adjusted to PH=6 with 0.1M NaOH, and sterilized at 120° C. for 30 minutes in a sterilizing pot. The solid base medium is m (corn flour): m (wheat bran): m (okara): 1:1:1, 1‰ peptone, adding appropriate amount of bagasse, the ratio of material to water is 10:3, and sterilized.

[0065] Seed culture: Add 150 ml of seed culture medium to a 500 ml Erlenmeyer flask, sterilize with steam at 120°C for 30 minutes, insert the strain after cooling, and place on a compound shaker at 120 rpm at a constant temperature of 26°C Shake continuously for 4 days to o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Biosynthesis of quinine compound and its optimizational ferment process. Strain is Ascomycetes Hypomyces(Fr) Tul.sp. Solid medium contains maize flour, wheat bran and bean dregs. Strain is switched in the medium after disinfection. Ferment at 24-25deg.C above 7 days. Fungus containing quinine compound is obtained. Break and dry the fungus, then extract to obtain the product.

Description

technical field [0001] The invention belongs to the biocatalytic synthesis technology of compounds, specifically the biosynthesis method of perylenequinone compounds, and particularly relates to the optimization of the fermentation process in the biosynthesis process. Background technique [0002] Perylenequinone compounds, such as coelomycin, hypocrellin A, hypocrellin B, etc., are a class of phytochromes distributed in nature. In recent years, it has been found that they have good photosensitivity to kill tumor cells and inhibit AIDS virus HIV-1, and are also used to treat skin diseases. Perylenequinone compounds are also potential new photoelectric conversion materials. The research on perylenequinone compounds as emerging photosensitive active pesticides is attracting the attention of scientists. Different species of fungi in nature can produce secondary metabolites containing the skeleton of perylenequinone compounds. Since the natural resources are very limited, som...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12P7/00C12P7/26
Inventor 李聪陈远腾台虹欧灵澄荷严萍
Owner YUNNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com