Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma

A production process, the technology of elemene, is applied in the production process field of extracting β-elemene anti-cancer raw material drug, which can solve the problem of large amount of β-elemene anti-cancer raw material drug and the industrial production level of β-elemene Low cost, too much feeding at one time, etc., to achieve good anti-cancer effect, strong anti-tumor effect, and good effect

Inactive Publication Date: 2005-10-26
仇德安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to overcome the problem of the low degree of industrial production of β-elemene existing in the prior art, and provide a production process for extracting β-elemene anticancer raw material medicine from C

Method used

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  • Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma
  • Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example one:

[0017] See figure 1 , A production process for extracting β-elemene anti-cancer raw materials from Wenyujin, using Wenyujin rhizome as the raw material to extract β-elemene, through steam distillation, multi-row simultaneous distillation, and precise fractionation to obtain anti-cancer drugs. Cancer raw materials.

Example Embodiment

[0018] Embodiment two:

[0019] See figure 1 with figure 2 , A production process for extracting β-elemene anti-cancer raw material medicine from Wenyujin:

[0020] a. Take the rhizome of Wenyujin, use steam distillation tower kettle to steam distillation to obtain turmeric volatile oil;

[0021] b. Take the zedoary turmeric oil obtained in step a, use the G-row synchronous rectification device for multi-row synchronous rectification, the vacuum degree is 1 ~ 3HHmg, and collect the fractions when the column temperature is 78 ~ 88 ℃;

[0022] c. Take the fractions collected in step b and add them to a flask under a precision fractionation column for precision fractionation. The precision fractionation column is filled with 2.5mm×2.5mm Q-type stainless steel, and the vacuum degree is 1~3HHmg. Collect the column temperature It is the fraction at 90-110°C to obtain the anti-cancer raw material drug with the content of β-elemene above 93%.

[0023] See figure 2 , The G-row synchronous...

Example Embodiment

[0027] Embodiment three:

[0028] See figure 1 with figure 2 , A production process for extracting β-elemene anti-cancer raw material medicine from Wenyujin:

[0029] a. Same as the second embodiment;

[0030] b. Same as Example 2, collect five fractions when the column temperature is 60~90℃;

[0031] c. Remove the second crystallization fraction obtained in step b, combine the first fraction and fourth fraction obtained in step b, and combine the third fraction and fifth fraction obtained in step b. Put them into two flasks under the same precision fractionation column. The precision fractionation column is filled with 2.5mm×2.5mm Q-type stainless steel, the vacuum degree is 1~3HHmg, and the four fractions are collected when the column temperature is 60~88℃. Then, the four fractions rectified from the two precision fractionation columns are combined in order. After testing, the content of β-elemene, δ-elemene and γ-elemene in each fraction is determined. Compared to an anti-canc...

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Abstract

The present invention relates to a production process for extracting beta-elemene anti-cancer raw material medicine from curcuma wenyujin. Said production process uses the rhizome of curcuma wenyujin as raw material, and adopts the procedures of steam distillation, muitirow synchronous distillation and precise fractionation so as to obtain the invented product.

Description

1. Technical field [0001] The invention relates to a preparation method of elemene, in particular to a production process for extracting β-elemene anticancer raw material medicine from curcuma mellifera. 2. Background technology [0002] In the 1970s, it was found that the zedoary oil extracted from Curcuma officinalis has antiviral and anti-tumor effects; in the 1990s, elemene was isolated from turmeric oil, and it was believed that elemene was an effective anti-tumor ingredient. Its preparations have Elemene Emulsion Injection. Elemene is regarded as a national second-class anti-cancer drug. But because the preparation produced by this crude drug contains a certain amount of impurity ingredients, there are many side effects, and its application range is subject to certain limitations. Therefore, people continued to conduct research and learned that the main active ingredient that has anti-tumor and can kill cancer cells is β-elemene, so β-elemene is reg...

Claims

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Application Information

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IPC IPC(8): C07C13/20
Inventor 仇德安
Owner 仇德安
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