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Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma

A production process, the technology of elemene, is applied in the production process field of extracting β-elemene anti-cancer raw material drug, which can solve the problem of large amount of β-elemene anti-cancer raw material drug and the industrial production level of β-elemene Low cost, too much feeding at one time, etc., to achieve good anti-cancer effect, strong anti-tumor effect, and good effect

Inactive Publication Date: 2005-10-26
仇德安
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0008] The object of the present invention is to overcome the problem of the low degree of industrial production of β-elemene existing in the prior art, and provide a production process for extracting β-elemene anticancer raw material medicine from Curcuma curcuma, which has a lot of one-time feeding, The amount of β-elemene anti-cancer raw materials collected is large, and the extraction time is greatly shortened compared with the existing technology, which is suitable for industrial production

Method used

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  • Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma
  • Production process for picking-up against cancer pharmaceutical product of beta element from Curcuma

Examples

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Embodiment 1

[0017] see figure 1 , a production process for extracting β-elemene anti-cancer raw materials from Curcuma curcuma, using the rhizome of Curcuma curcuma as the raw material for extracting β-elemene, and obtaining anti-cancer drugs through steam distillation, multi-row synchronous rectification, and precision fractionation. Cancer Raw Drugs.

Embodiment 2

[0019] see figure 1 and figure 2 , a production process for extracting β-elemene anti-cancer raw material drug from Curcuma curcuma:

[0020] a. get the positive rhizome of Wen Yujin, and use the steam distillation tower kettle to carry out steam distillation to obtain the zedoary zedoary volatile oil;

[0021] b. Get the zedoary zedoary volatile oil obtained in a step, adopt G-row type synchronous rectification device to carry out multi-row synchronous rectification, the vacuum degree is 1~3HHmg, and the fraction when collecting column temperature is 78~88 ℃;

[0022] c. Take the fraction collected in step b and add it to a flask under a precision fractionation column for precision fractionation. The precision fractionation column is filled with 2.5mm×2.5mm Q-type stainless steel, and the vacuum degree is 1-3HHmg. It is a fraction at 90-110 DEG C, and an anticancer raw material drug with a content of β-elemene of more than 93% is obtained.

[0023] see figure 2 , the G-...

Embodiment 3

[0028] see figure 1 and figure 2 , a production process for extracting β-elemene anti-cancer raw material drug from Curcuma curcuma:

[0029] A. with embodiment two;

[0030] b. with embodiment two, five cuts when collecting column temperature are 60~90 ℃;

[0031] c. remove the second crystallization cut that b step obtains, get the first cut that b step obtains and the fourth cut merge, get the third cut that b step obtains and the fifth cut merge, Put them into two flasks under the same precision fractionation column respectively. The precision fractionation column is filled with 2.5mm×2.5mm Q-type stainless steel. Then the four fractions from the two precision fractionation columns were combined in order, and the content of β-elemene, δ-elemene and γ-elemene in each fraction was determined after testing. It is compared to an anticancer raw material drug containing 70-85% of β-elemene, 1-16% of the sum of δ-elemene and γ-elemene, and more than 86% of the sum of elemene...

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Abstract

The present invention relates to a production process for extracting beta-elemene anti-cancer raw material medicine from curcuma wenyujin. Said production process uses the rhizome of curcuma wenyujin as raw material, and adopts the procedures of steam distillation, muitirow synchronous distillation and precise fractionation so as to obtain the invented product.

Description

1. Technical field [0001] The invention relates to a preparation method of elemene, in particular to a production process for extracting β-elemene anticancer raw material medicine from curcuma mellifera. 2. Background technology [0002] In the 1970s, it was found that the zedoary oil extracted from Curcuma officinalis has antiviral and anti-tumor effects; in the 1990s, elemene was isolated from turmeric oil, and it was believed that elemene was an effective anti-tumor ingredient. Its preparations have Elemene Emulsion Injection. Elemene is regarded as a national second-class anti-cancer drug. But because the preparation produced by this crude drug contains a certain amount of impurity ingredients, there are many side effects, and its application range is subject to certain limitations. Therefore, people continued to conduct research and learned that the main active ingredient that has anti-tumor and can kill cancer cells is β-elemene, so β-elemene is reg...

Claims

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Application Information

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IPC IPC(8): C07C13/20
Inventor 仇德安
Owner 仇德安
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