Carrier of separating amino acid preparation method thereof
An amino acid and carrier technology, applied in the field of functional polymers, can solve the complex effects of resin performance and other problems, and achieve the effect of improving multiple substitutions and post-crosslinking, clear structure, and fewer reaction steps
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Embodiment 1
[0030] Take 1 g of polystyrene (crosslinking degree: 7% DVB, particle size: 8 μm) into a three-necked reaction flask, add anhydrous dichloromethane to swell, stir to make it evenly dispersed, add 0.8 ml of chloroacetyl chloride dropwise, and pass nitrogen gas , 1.3g of aluminum trichloride was added under stirring, and the reaction was carried out at room temperature and pressure for 4.5h. That is, chloroacetylated polystyrene with a supported amount of 4.1 meq / g was obtained.
[0031] Take 1g of the above resin in a round-bottomed beaker, add 5ml of tetrahydrofuran, swell for 12h, add 5ml of 50% NaOH solution, stir evenly, then add 1.0g of L-phenylalanine and 0.15g of tetra-n-butylammonium chloride, stir to make it Disperse uniformly and react at 90°C for 24h under normal pressure. That is, an amino acid resin with a loading amount of 1.8 meq / g was obtained.
Embodiment 2
[0033] Take 1 g of polystyrene (crosslinking degree: 7% DVB, particle size: 200 μm) into a three-necked reaction flask, add anhydrous dichloromethane to swell, stir to make it evenly dispersed, add 0.16 ml of chloroacetyl chloride dropwise, and introduce nitrogen , 0.26g of aluminum trichloride was added under stirring, and the reaction was carried out at room temperature and pressure for 1h. That is, the loading amount is 1.5 meq / g of chloroacetylated polystyrene.
[0034] Take 1g of the above resin in a round-bottomed beaker, add 5ml of tetrahydrofuran, swell for 12h, add 10ml of 45% NaOH solution, stir well, then add 0.8g of L-tyrosine and 0.2g of benzyltriethylammonium chloride, stir to make it Disperse uniformly and react at 90°C for 48h under normal pressure. That is, an amino acid resin with a loading amount of 1.2 meq / g was obtained.
Embodiment 3
[0036] Take 10 g of polystyrene (crosslinking degree: 7% DVB, particle size: 200 μm) into a three-necked reaction flask, add anhydrous dichloromethane to swell, stir to make it evenly dispersed, add 0.3 ml of bromoacetyl bromide dropwise, and introduce nitrogen , 1.4g of zinc chloride was added under stirring, and the reaction was carried out at room temperature and pressure for 0.5h. That is, a loading amount of 0.98 meq / g of bromoacetylated polystyrene was obtained.
[0037] Take 1g of the above resin in a round-bottomed beaker, add 5ml of ethanol, swell for 12h, add 10ml of 33% NaOH solution, stir well, then add 0.8g L-phenylalanine and 0.2g benzyltriethylammonium chloride, stir to make The dispersion was uniform, and the reaction was carried out at 70 °C for 6 h under normal pressure. That is, an amino acid resin with a loading amount of 0.6 meq / g was obtained.
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