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Process for preparing fluoro methyl ether

A monochloromethyl ether, fluorine technology, applied in the preparation of organic compounds, chemical instruments and methods, organic chemistry and other directions, can solve problems such as low reaction conversion rate

Active Publication Date: 2005-11-23
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, U.S. Patent 4874901 has reported that under the conditions of high temperature and high pressure, chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether reacts with pure potassium fluoride, but the reaction conversion rate is relatively low. Low

Method used

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  • Process for preparing fluoro methyl ether
  • Process for preparing fluoro methyl ether
  • Process for preparing fluoro methyl ether

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 500g of chloromethyl ether, 100g of sodium fluoride and 45g of ethylene glycol into a 500mL single-necked bottle with a magnetic stirring and reflux device, heat and reflux for 5 hours, and after the reaction is completed, 432.2g is obtained by distillation, which contains heptafluoride after analysis Alkanes 96.5%, yield: 90.3%.

Embodiment 2

[0026] Add 500g of chloromethyl ether, 140g of potassium fluoride, 400mL of sulfolane and 60g of 18-crown ether-6 into a 1000mL single-necked bottle equipped with a magnetic stirring and reflux device, heat and reflux for 2 hours, and after the reaction is completed, 419.6g of the product is obtained by distillation After analysis, it contains 95.3% of sevoflurane, and the yield is 86.6%.

Embodiment 3

[0028] Add 500g of chloromethyl ether, 80g of potassium fluoride and 30g of 18-crown-6 into a 500mL single-necked bottle equipped with a magnetic stirring and reflux device, heat and reflux for 4 hours, and after the reaction is completed, 236.6g of the product is obtained by distillation and recovered 204.2g of chloromethyl ether, the product contains 98.8% of sevoflurane after analysis, yield: 84.6%.

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Abstract

The invention relates to a process for preparing propylene glycol ester, more specifically fluoromethyl-2,2,2-trifluo-1-(trifluoromethyl) ethyl ether (sevoflurane), wherein the precursor reacts with fluorides at the presence of activating agents.

Description

technical field [0001] The present invention relates to a method for preparing monofluoromethyl ethers, especially fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane). technical background [0002] In recent years it has been discovered that fluorinated ethers are effective inhalational anesthetics. Included among these anesthetics is desflurane (CF 3 CHFOCHF 2 ), isoflurane (CF 3 CHClOCHF 2 ), enflurane (ClFCHCF 2 OCHF 2 ) and sevoflurane ((CF 3 ) 2 CHOCH 2 F). Sevoflurane is a particularly advantageous inhalational anesthetic because of its rapid loss of consciousness and rapid recovery—ideal properties of contemporary inhalational anesthetics. Sevoflurane is delivered to an air-breathing warm-blooded animal through the inhalation route at about 1% to 5% by volume in a mixture with oxygen or in a gaseous mixture containing sufficient oxygen to maintain respiration. [0003] U.S. Patent 3683092 and 3689571 disclose the use of sevoflurane as ...

Claims

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Application Information

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IPC IPC(8): C07C43/12
Inventor 赵志全彭立增提文利
Owner SHANDONG NEWTIME PHARMA
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