Medicinal composition of silibin

A technology of silibinin and its composition, which is applied in the pharmaceutical composition of silybin and its preparation field, can solve the problems of difficulty in preparing pure lecithin, increased preparation cost, unstable properties, etc., and achieve production cost Low, fat-soluble increase, the effect of reducing production cost

Inactive Publication Date: 2006-01-04
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of pure lecithin is very difficult, expensive and unstable, so not only the preparation cost is greatly increased, but also the properties are very unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of silybin:

[0031] Take a certain amount of milk thistle seeds, crush them, place them in a Soxhlet extractor and extract them with ethyl acetate for 20 hours, concentrate the extract in a rotary evaporator, recover the solvent, and obtain a brown-yellow extract. Wash the surface oil with petroleum ether to obtain a paste Crude silybin. After degreasing, recrystallization and drying, 350 g of silybin was obtained.

[0032] Preparation of the product:

[0033] a. Take 350g of silibinin, orally take 650g of soybean lecithin, 1000g of lactose, and 500g of talcum powder;

[0034] b. Add the above-mentioned silibinin and oral soybean lecithin to 15000ml of absolute ethanol, heat and reflux for 1 hour to make the solution clear;

[0035] c. Concentrate under reduced pressure at 70°C to 1500ml, and continue drying at 40°C to obtain a silybin-lecithin dispersion;

[0036] d. Mix the silibinin-lecithin dispersion obtained in step c with pre-dried auxiliary mate...

Embodiment 2

[0038] The preparation of silybin: with embodiment 1.

[0039] Preparation of the product:

[0040] a. Take 350g of silibinin, 350g of soybean lecithin, 1000g of lactose, and 500g of talcum powder;

[0041] b. Add the above-mentioned silibinin and oral soybean lecithin to 15000ml of absolute ethanol, heat and reflux for 1 hour to make the solution clear;

[0042] c. Concentrate under reduced pressure at 70°C to 1500ml, and continue drying at 40°C to obtain a silybin-lecithin dispersion;

[0043] d. Mix the silibinin-lecithin dispersion obtained in step c with pre-dried auxiliary materials to make 10,000 capsules.

Embodiment 3

[0045] The preparation of silybin: with embodiment 1.

[0046] Preparation of the product:

[0047] a. Take 350g of silibinin, orally take 1400g of soybean lecithin, 1000g of lactose, and 500g of talcum powder;

[0048] b. Add the above-mentioned silibinin and oral soybean lecithin to 15000ml of absolute ethanol, heat and reflux for 1 hour to make the solution clear;

[0049] c. Concentrate under reduced pressure at 70°C to 1500ml, and continue drying at 40°C to obtain a silybin-lecithin dispersion;

[0050] d. Mix the silibinin-lecithin dispersion obtained in step c with pre-dried auxiliary materials to make 10,000 capsules.

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PUM

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Abstract

The present invention discloses a kind of medicinal composition containing silibin and its preparation process. Specifically, silibin and phosphatide are dissolved in organic solvent, the solution is heated and refluxed until becoming clear, and the solution is decompression concentrated to certain volume to obtain phosphatide dispersed matter, and the phosphatide dispersed matter is dried to obtain the medicinal composition.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicinal composition of silybin and a preparation method thereof. Background technique [0002] Milk thistle is a plant of Compositae native to southern Europe and North Africa. It is used in folk medicine to treat liver diseases. In 1968, Wagner et al. extracted a flavonoid compound 1 from it and named it silymarin (Sily marin). It has been proved that the main component of silymarin is silybin (Silybin, Sil) There are two isomers, Silydianin and Silychristinin. Experiments show that silybin has various pharmacological effects, which are briefly described as follows. [0003] Liver protection [0004] Silibinin can counteract the damage effect of various poisons and drugs on the liver. Such as Sil can reduce the toxic effect of carbon tetrachloride on the liver. As for the mechanism of hepatoprotective action, some studies suggest that Sil c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61K9/20A61K9/48A61P1/16A61P3/06
Inventor 任晓文章顺楠刘金平潘勤杨健会张洪坡
Owner TIANJIN TASLY PHARMA CO LTD
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