Medicine contained soft capsule

A technology of soft capsules and soft capsules, which is applied in capsule delivery, drug combination, and pharmaceutical formulations, and can solve problems such as reduced drug efficacy, crystal form changes, and high bioavailability

Active Publication Date: 2006-02-15
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is well known to those skilled in the art that the crystal form of a drug is closely related to drug efficacy and side effects of the drug. The crystal form of the crystalline drug in the solution often changes or the drug aggregates, which may reduce the drug effect or increase the toxic and side

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription

[0030] Component Content (mg / capsule / grain)

[0031] Anetellithin 50

[0032] PEG-400 300

[0033] PEG-2000 4

[0034] PEG-6000 6

[0035] Tween-80 2

[0036] Glycerin 4

[0037] Total 366

[0038] Process:

[0039] Take the raw material of anetis trisulfide, crush it, pass it through a 200-mesh sieve, and set it aside.

[0040] Take the prescription amount of PEG-2000, PEG-6000, after heating and melting, add the prescription amount of PEG-400, glycerin and Tween-80, after stirring evenly, add anetisone at about 40°C, stir well to make it completely mixed evenly, Processed into soft capsules.

Embodiment 2

[0042] prescription

[0043] Component Content (mg / capsule / grain)

[0044] Anetellithin 25

[0045] PEG-400 500

[0046] PEG-4000 26

[0047] Sodium Lauryl Sulfate 5

[0048] Total 556

[0049] Process:

[0050] Take the raw material of anetisol, pulverize it, pass it through a 180-mesh sieve, and set it aside.

[0051] Take the prescribed amount of PEG-4000, heat and melt, add the prescribed amount of PEG-400 and sodium lauryl sulfate, stir evenly, then add anetis trisulfide at about 40°C, stir well to make it completely mixed evenly, and process it into a soft capsule .

Embodiment 3

[0053] prescription

[0054] Component Content (mg / capsule / grain)

[0055] Anetellithin 12.5

[0056] PEG-200 400

[0057] PEG-6000 10

[0058] Sorbitol 5

[0059] Total 427.5

[0060] Process:

[0061] Take the raw material of anetis trisulfide, pulverize it, pass through a 150-mesh sieve, and set aside.

[0062] Take the prescribed amount of PEG-6000, heat and melt it, add the prescribed amount of PEG-400 and sorbitol, stir evenly, add anetis trisulfide at about 40°C, stir well to make it completely mixed evenly, and process it into a soft capsule.

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PUM

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Abstract

The invention relates to a medicinal oral preparation containing anethol trithione, more specifically, the invention relates to a soft capsule for enhancing the beneficial effects of the anethol trithione.

Description

technical field [0001] The present invention relates to the pharmaceutical oral preparation containing anetis, in particular relates to the soft capsule dosage form which enhances the beneficial effect of anetis. Background technique [0002] Anethol trithione, also known as bilivitamin and anethole trithione, has definite curative effects on choleretic, liver protection, delay, detoxification, and digestion promotion, especially in choleretic and liver protection. Biochemical studies have shown that the drug can significantly enhance the vitality of liver cells and increase the secretion of bile. Anetis trithione belongs to secretory choleretic drugs, which is different from excretory choleretic drugs, it does not increase the burden on the liver, on the contrary, it can significantly reduce the portal vein pressure of the liver, promote the activation of liver cells, and help the liver function to return to normal. [0003] At present, the dosage form of the drug on the m...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61K9/48A61P1/16
Inventor 姚俊华
Owner 江苏万高药业股份有限公司
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