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Process for preparing nanometer particle of adriacin-PACA-PBCA

A polycyanoacrylate n-butyl ester and nanoparticle technology, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as loss of treatment opportunities, and reduce drug Dosage and frequency of administration, effect of improving curative effect, increasing concentration and duration of action

Inactive Publication Date: 2006-02-15
张阳德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxic and side effects of chemotherapy make those with poor liver function and general condition lose the chance of treatment

Method used

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Examples

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Embodiment Construction

[0006] The present invention will be described in detail below in conjunction with the embodiments.

[0007] Use a pipette to take 50ml of 0.1N HCl solution and place it in a conical flask, add 10mg of doxorubicin hydrochloride powder dried to constant weight, stir to dissolve, and then add 1.5% Dextran with a micropipette 70 0.3ml, under the action of a magnetic stirrer, slowly add 0.2ml of n-butyl α-cyanoacrylate, stir while adding dropwise, and control the addition within 10 minutes. Close the mouth of the bottle and keep stirring at 1000rpm for 3h. When orange-yellow opalescence appears, adjust the pH to 7 with 0.2N NaOH solution and pass through a 0.45μm filter membrane. The filtrate is dried in a vacuum oven at 25°C and -0.1kPa to obtain the present invention.

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Abstract

The invention provides a process for preparing nanometer particle of adriacin-PACA-PBCA, which comprises, reacting HCl solution with doxorubicin hydrochloride powder, stirring to dissolve, charging Dextran70 and charging alpha-butylcyanoacrylate, stirring and adjusting pH to be 7, passing through 0.45um filtration film and drying.

Description

technical field [0001] The invention relates to a preparation method of drug nanoparticle for treating liver cancer. technical background [0002] Liver cancer is one of the most common malignant tumors in the world. At present, surgical resection is still the main treatment for liver cancer, and chemotherapy is still required in many cases. However, the toxic and side effects of chemotherapy make those with poor liver function and general condition lose the chance of treatment. In recent years, gene therapy has been produced and developed, but the prerequisite for effective gene therapy is that nucleic acid molecules must be effectively delivered to target cells. Contents of the invention [0003] The object of the present invention is to provide a preparation method of doxorubicin-polycyanoacrylate n-butyl ester nanoparticles (DOX-PBCA-NP) with strong targeting. [0004] The preparation method of DOX-PBCA-NP of the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/14A61K47/32A61P35/00
CPCA61K9/5138A61K47/48176A61K47/4823A61K47/58A61K47/61A61P35/00
Inventor 张阳德
Owner 张阳德
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