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Preparation process and use of birds calamus made artificial nerve bridge connection tube

A technology for artificial nerves and poultry feathers, which is used in medical science, prostheses, etc.

Inactive Publication Date: 2006-02-22
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relatively complete substitute product for clinical repair of nerve defects, and several materials under research are in the experimental stage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Select 20 g of chicken feathers with a length of 15 mm to 20 mm and a diameter of 2.5 mm to 3 mm, clean them with an ultrasonic cleaner plus 3% aqueous detergent solution, and dry them at 70° C.±10° C. With 15mol / L C 2 h 6 O 200mL at 30°C for 10 hours to degrease, wash with distilled water, and dry at 70°C±10°C. With 0.1mol / L C 4 h 10 o 2 S 2 150mL, treated at 35°C for 6 hours. Wash the reagents with distilled water and dry at 70°C±10°C. With 0.3mol / L C 2 h 4 o 2 250mL, treated at 28°C for 5 hours. Rinse with distilled water to pH 5-7, and dry at 70°C±10°C. Treat with 200mL of 0.8mol / L N2H4CO at 32°C for 8 hours. Wash the reagents with distilled water and dry at 70°C±10°C. Treat with 0.4mol / L KOH 250mL at 32°C for 12 hours. Rinse with distilled water to pH 6.0-7.5, and dry at 70°C±10°C to prepare chicken feather root artificial nerve bridge.

Embodiment 2

[0017] Select 20 g of chicken feathers with a length of 15 mm to 20 mm, clean them with an ultrasonic cleaner plus 3% aqueous solution of detergent, and dry them at 70° C. ± 10° C. With 9.6mol / L (CH 3 CH 2 ) 2 O 250mL, degrease at 20°C for 5 hours, rinse with distilled water, and dry at 70°C±10°C. 0.8mol / L C 2 h 6 OS 200mL, treated at 40°C for 7 hours. Wash the reagents with distilled water and dry at 70°C±10°C. Treat with 240 mL of 0.2 mol / L HCl at 25°C for 6 hours. Rinse with distilled water to pH 5-7, and dry at 70°C±10°C. With 0.5mol / L CH 5 N 3 .HCl 200mL, treated at 28°C for 5 hours. Wash the reagents with distilled water and dry at 70°C±10°C. With 0.6mol / L NH 4 OH 250mL, treated at 30°C for 16 hours. Rinse with distilled water to pH 6.0-7.5. Dry at 70°C±10°C to prepare chicken feather root artificial nerve bridge.

Embodiment 3

[0019] Select 20 g of chicken feathers with a length of 15 mm to 20 mm, clean them with an ultrasonic cleaner plus 3% aqueous solution of detergent, and dry them at 70° C. ± 10° C. With 13.6mol / L CH 3 COCH 3 Degrease 200mL at 24°C for 8 hours, rinse with distilled water, and dry at 70°C±10°C. Treat with 200 mL of 0.5 mol / L HCOOOH at 25°C for 6 hours. Rinse with distilled water to pH 5-7, and dry at 70°C±10°C. With 0.1mol / L C 12 h 25 o 4 S.Na 250mL, treated at 38°C for 8 hours. Wash the reagents with distilled water and dry at 70°C±10°C. With 1.0mol / L Na 2 CO 3 250mL, treated at 32°C for 24 hours. Rinse with distilled water to pH 6.0-7.5. Dry at 70°C±10°C to prepare chicken feather root artificial nerve bridge.

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Abstract

The invention discloses a making method and usage of artificial feather-root neurobridge-pipe and neurobridge-filament, which is characterized by the following: cleaning the feather-root; degreasing; disposing feather-root protein to change its structure by the disulfide bond reducer, acid, polypeptide chain non-covalent bond denaturant and alkali; the bulk factor of feather-root and the each relating reagent weight is 5%-20%; the adaptation density of reagent is (0.1-1.0)mol / L; the temperature and time of each processing procedure is 20 Deg C.-40Deg C. and 5-30 hours separately; adapting frozen section method to cut the disposal feather-root into the filament with the diameter of 20mu m-100mu m; formatting the bridge-filament. The method provides a transient succedaneum of injured peripheral nerve of human reconditioning arrangement for medical traumatology department.

Description

technical field [0001] The invention relates to a poultry feather artificial nerve bridging tube and bridging wire; the invention also relates to a preparation method and application of the poultry feather artificial nerve bridging tube and bridging wire. Background technique [0002] A variety of traumas can cause damage to peripheral nerves. According to statistics, the incidence of peripheral nerve injury accounts for about 3-5% of injuries in peacetime and 5-10% of injuries in wartime; wherein nerve injuries in limbs account for about 10-20% (in peacetime) and 60% (in wartime). The repair of peripheral nerve defects has always been a hot issue, especially the loss of a long segment of nerves will bring a lot of inconvenience to the life of patients in the future, and it is imminent to study the method of repairing peripheral nerve injuries. [0003] Studies have found that nerve regeneration requires a good microenvironment, which is suitable for the three-dimensional s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61L27/38
Inventor 董为人肖应庆
Owner SOUTHERN MEDICAL UNIVERSITY
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