Selective androgen receptor modulators and methods of use thereof

An androgen receptor, selective technology, applied in the direction of diseases, pharmaceutical formulations, organic active ingredients, etc., can solve the problem of non-steroidal androgen reports and other issues
CN1736981AInactive Publication Date: 2006-02-22UNIV OF TENNESSEE RES FOUND
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
UNIV OF TENNESSEE RES FOUND
Publication Date
2006-02-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.
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Description

[0001] This application is a divisional application of Chinese patent application 01817889.8 filed on August 23, 2001, with the invention title "Selective Androgen Receptor Modulator and Its Application Method". technical field

[0002] The present invention relates to a new class of tissue selective androgen receptor targeting agents (ARTAs) which exhibit androgenic and anabolic activity of non-steroidal ligands of the androgen receptor. Targeted Agents Definition Those are a new subclass of compounds that are Tissue Selective Androgen Receptor Modulators (SARMs) that are useful in androgen therapies such as oral testosterone replacement therapy, male contraception, maintenance of libido in women, treatment of prostate cancer and imaging of prostate cancer it works. These agents are also administered to subjects for the treatment of sarcopenia, loss of libido, osteoporosis, erythropoiesis, and fertility. Targeting agents can be used alone or in combination with progesterone ...

Claims

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