Saccharide composition with protection on microecologic prepn

A probiotic and protective technology, applied in the field of medicine, can solve the problems of limited promotion and application, increased circulation cost, low bacterial survival rate, etc., and can reduce blood cholesterol and triglyceride, inhibit tumor occurrence, and enhance body immunity. effect of function

Inactive Publication Date: 2006-03-01
CHINA AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The micro-ecological products currently on the market have a low survival rate of bacteria, and all of them need to b...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 0.01 g of hyaluronic acid and 1 g of trehalose, dissolve and mix them with deionized water, set the volume to 10 ml, filter and sterilize with a 0.22 μm microporous membrane to obtain the protective agent of the present invention. Take 0.5 mL of the above protective agent, weigh 0.1 mg of the wet bacterial cells after centrifugation, and suspend in the protective agent. Add a certain amount of bifidofactors that have been sterilized in advance as needed to obtain a mixed bacterial solution.

[0034] The mixed bacteria solution was divided into sterile glass bottles with stoppers, pre-frozen to about -35°C, and then placed in a freeze dryer for about 25 hours to freeze-dry to obtain freeze-dried bacteria powder. Residual moisture in the product is required to reach 2% to 3%.

Embodiment 2

[0036] Take 0.01 g of hyaluronic acid and 1 g of trehalose, dissolve and mix them with deionized water, set the volume to 10 ml, filter and sterilize with a 0.22 μm microporous membrane to obtain the protective agent of the present invention. Take 0.5 mL of the above protective agent, weigh 0.1 mg of the wet bacterial cells after centrifugation, and suspend in the protective agent. Add a certain amount of bifidofactors that have been sterilized in advance as needed to obtain a mixed bacterial solution.

[0037] Pack the mixed bacteria solution into sterile glass bottles with stoppers, put them in a vacuum dryer at a vacuum degree of 20-30 Pa and a product temperature of 30°C for about 48 hours to obtain dried bacteria powder. Residual moisture in the product is required to reach 2% to 3%.

Embodiment 3

[0039] Take 0.01 g of hyaluronic acid and 1 g of trehalose, dissolve and mix them with deionized water, set the volume to 10 ml, filter and sterilize with a 0.22 μm microporous membrane to obtain the protective agent of the present invention. Take 0.5 mL of the above protective agent, weigh 0.1 mg of the wet bacterial cells after centrifugation, and suspend in the protective agent. Add a certain amount of bifidofactors that have been sterilized in advance as needed to obtain a mixed bacterial solution.

[0040] The mixed bacteria solution was divided into aseptic stoppered glass bottles, and spray-dried in a centrifugal spray dryer with an inlet temperature of 120°C and an outlet temperature of 80°C to obtain dry bacteria powder. Residual moisture in the product is required to reach 2% to 3%.

[0041] Experimental research data of the present invention

[0042] In this experiment, the bacterial solution without protective agent was freeze-dried in the same way as the negativ...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is one saccharide composition for protecting microecologic preparation. The microecologic preparation for maintaining health includes bifidobacterium, lactobacillus, etc. The saccharide composition consists of hyaluronic acid and mycose and has double and synergistic protection on microecologic preparation in drying and storage process. The saccharide composition can raise the survival rate of microbes, prolong the survival period, and makes it possible to maintain microecologic preparation.

Description

Technical field: [0001] The invention relates to a carbohydrate combination (protective agent) capable of protecting microecological preparations during drying and storage, and belongs to the technical field of medicines. Background technique: [0002] In the past 10 years, with the rapid development of microecology in my country, a new class of drugs and health food based on microecological preparations have been or are forming industries, and have become important biological agents for people to prevent diseases and maintain health. It not only has quick and short-term effects, such as: prevention and treatment of acute and chronic diarrhea, constipation, and improvement of gastrointestinal function. There are also significant long-term effects, such as: by reducing the level of toxins in the human body, improving nutritional status, promoting liver cell growth, improving human immunity, etc., it can protect the liver and help improve symptoms of liver diseases; 1. Advers...

Claims

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Application Information

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IPC IPC(8): A61K47/36C12N1/20
Inventor 籍保平张玉华凌沛学张桂芝
Owner CHINA AGRI UNIV
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