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Traditional Chinese medicine compositions for AIDS and its preparation method and uses

A technology of HIV and composition, applied in the field of anti-HIV traditional Chinese medicine composition, its preparation and use, can solve the problems of only injection, high price, not oral administration and the like

Active Publication Date: 2006-04-05
BEIJING CENTURY HEALTH MEDICAL & PHARMA DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned earlier, although T20 can block viruses from entering cells, because T20 is a peptide, it cannot be taken orally, it can only be injected, and the price is very expensive

Method used

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  • Traditional Chinese medicine compositions for AIDS and its preparation method and uses
  • Traditional Chinese medicine compositions for AIDS and its preparation method and uses
  • Traditional Chinese medicine compositions for AIDS and its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of pharmaceutical composition of the present invention:

[0037] Take 180kg of Scutellaria baicalensis and 150kg of Rubia crude drug, crush them, add 1400L of 50% ethanol to soak for 6 hours; pour the soaked raw material medicine and soaking liquid into a diafiltration tank for diafiltration, and the speed of diafiltration is 3-4.5ml / kg.min -1 Add ethanol in stages successively, continue diafiltration, and collect 4000L leachate; concentrate the leachate by reclaiming ethanol, so that compared with water, the weight ratio of the concentrated solution finally obtained is water: concentrated solution=1: 1.1~1.35 Spray-dry the above concentrate into powder; the yields of the extract powders of Scutellaria baicalensis and Rubia baicalensis are 8-10% and 10-15% respectively, therefore, the obtained dry powder is equivalent to 18kg Scutellaria baicalensis extract powder and 17kg Rubia baicalensis extract powder. And the dry powder obtained is mixed with 18kg g...

Embodiment 2

[0039] Take 180kg of Scutellaria baicalensis crude drug, pulverize it, add 720L of 50% ethanol to soak for 6 hours; pour the soaked crude drug and soaking liquid into a diafiltration tank for diafiltration, and the diafiltration speed is 3-4.5ml / kg.min -1 50% ethanol in succession, continue to diafiltration, collect leachate 2200L; Concentrate the leachate by volatile ethanol, make compared with water, the weight ratio of the concentrated solution that finally obtains is water: concentrated solution=1: 1.1~ 1.35; the above concentrated solution was spray-dried into powder to obtain 18kg Scutellaria baicalensis extract powder.

[0040] Take 150kg Rubia crude drug, crush it, add 600L of 40% ethanol and soak for 6 hours; pour the soaked crude drug and the soaking liquid into a percolation tank for percolation, and the percolation speed is 3-4.5ml / kg.min -1 Add 40% ethanol successively, continue to diafiltration, collect leachate 1800L; Concentrate leachate by volatile ethanol, ma...

experiment example 1

[0043] Clinical trials of the pharmaceutical composition of the present invention

[0044] Source of patients: After treating 1,000 patients in Xincai County and Shangqiu, Henan Province in 2002, blood was drawn from 60 patients. The sample selection points were people infected with AIDS by selling blood from 1992 to 1995. A total of 60 people, among them There are 19 males and 41 females, the oldest is 58 years old, the youngest is 27 years old, and the average age is 38.9 years old. They are all farmers. Among them, 59 hepatitis C antibody tests were positive, 7 were positive for syphilis PPR, 2 were combined with tuberculosis infection, and the hepatitis B tests were all negative.

[0045] Medication method: 3 times a day, 4 capsules each time, orally.

[0046] 1. Changes in viral load before and after treatment :

[0047] The patient's blood was drawn before treatment and 6 months after treatment, centrifuged to obtain plasma, and stored at -80°C. During detection, RNA...

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Abstract

The invention relates to a medicinal composition containing baikal skullcap root extracted powder, radix rubiae extracted powder, panaxoside powder and Chinese caterpillar fungus powder. The invention also relates to the process for preparing the medicinal composition and its use in treating AIDS.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing scutellaria baicalensis extract powder, madder extract powder, ginsenoside powder and cordyceps sinensis powder. The present invention further relates to the preparation method of the pharmaceutical composition and the use of the medicine for treating AIDS. Background technique [0002] Scutellaria baicalensis is a heat-clearing and damp-drying medicine. It is the root of Scutellaria baicalensis Georgi, a plant in the Labiatae family. It mainly contains flavonoids, and its main functions are anti-inflammatory, anti-allergic, anti-pathogenic microorganisms, antipyretic and detoxification. Rubia, also known as Qiangen, Xuejianshou, Huoxuecao, is the dry heel and rhizome of Rubia cordifolia L. The active ingredient cyclohexyl peptides are also rich in calcium ions, etc., which have the functions of cooling blood to stop bleeding, removing blood stasis and promoting blood circulation, anti-c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K36/068A61P31/18
CPCA61K36/068A61K36/74A61K36/539A61K36/258A61P31/18A61K2300/00
Inventor 李泽琳曾越曾毅曾欣
Owner BEIJING CENTURY HEALTH MEDICAL & PHARMA DEV
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